Skip to main content
SpringerLink
Log in
Birkhäuser

Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

  • Book
  • © 2005

Overview

Editors:
  1. Annika B. Malmberg

    1. Elan Pharmaceuticals, South San Francisco, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Keith R. Bley

    1. NeurogesX, Inc., San Carlos, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First comprehensive volume on this timely topic
  • Discusses the therapeutic potential of TRPV1
  • Written by well-known scientists in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Historical perspective on capsaicin and its receptor

    1. Hot peppers, pain and analgesics

      • János Szolcsányi
      Pages 3-22

  3. Molecular and cellular properties of vanilloid receptors

    1. Structural determinants of TRPV1 functionality

      • Makoto Tominaga
      Pages 25-37

    2. TRPV1 distribution and regulation

      • Janet Winter
      Pages 39-51

  4. Pharmacology and physiology of vanilloid receptors

    1. Insights into TRPV1 pharmacology provided by non-capsaicin ligands

      • Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets, Larry V. Pearce
      Pages 55-69

    2. Endocannabinoids and vanilloid TRPV1 receptors

      • Ruth A. Ross
      Pages 71-93

    3. Vanilloid receptor-mediated hyperalgesia and desensitization

      • Zoltán Sándor, Arpad Szallasi
      Pages 95-115

    4. Capsaicin in human experimental pain models of skin, muscle and visceral sensitization

      • Lars Arendt-Nielsen, Ole K. Andersen
      Pages 117-144

  5. Vanilloid receptor involvement in disease states

    1. TRPV1 in gut function, abdominal pain and functional bowel disorders

      • Peter Holzer
      Pages 147-165

    2. TRPV1 in the airways

      • Maria G. Belvisi, Peter J. Barnes
      Pages 167-187

  6. Therapeutic potential of vanilloid agonists and antagonists

    1. TRPV1 agonist-based therapies: mechanism of action and clinical prospects

      • Keith R. Bley, Annika B. Malmberg
      Pages 191-209

    2. TRPV1 agonist therapies in bladder diseases

      • Francisco Cruz, Carlos Silva, Paulo Dinis
      Pages 211-225

    3. TRPV1 antagonists and chronic pain

      • Kenneth J. Valenzano, James D. Pomonis, Katharine Walker
      Pages 227-243

  7. Back Matter

    Pages 245-252
    Download chapter PDF
Back to top

Keywords

About this book

Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.

Editors and Affiliations

  • Elan Pharmaceuticals, South San Francisco, USA

    Annika B. Malmberg

  • NeurogesX, Inc., San Carlos, USA

    Keith R. Bley

Bibliographic Information

  • Book Title: Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

  • Editors: Annika B. Malmberg, Keith R. Bley

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/3-7643-7379-2

  • Publisher: Birkhäuser Basel

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Birkhäuser Basel 2005

  • Hardcover ISBN: 978-3-7643-7080-0Published: 15 August 2005

  • eBook ISBN: 978-3-7643-7379-5Published: 17 January 2006

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: XII, 249

  • Topics: Pain Medicine, Immunology, Neurosciences, Pharmacology/Toxicology, Cell Biology

Publish with us

Policies and ethics

Back to top

Search

Navigation