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Mechanisms of Angiogenesis

  • Book
  • © 2005

Overview

Editors:
  1. Matthias Clauss

    1. Department of Cellular and Integrative Physiology, Indiana Center for Vascular Biology and Medicine, Indianapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Georg Breier

    1. Institute of Pathology, University Clinic Carl Gustav Carus TU Dresden, Dresden, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A concise compilation of current knowledge on angiogenesis
  • Presents new targets for medical intervention
  • Provides insight into molecular mechanisms of blood vessel growth

Part of the book series: Experientia Supplementum (EXS, volume 94)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XIV
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  2. Basic principles in physiological and pathophysiological angiogenesis

    1. How do endothelial cells orientate?

      • Holger Gerhardt, Christer Betsholtz
      Pages 3-15

    2. New insights into intussusceptive angiogenesis

      • Valentin Djonov, Andrew N. Makanya
      Pages 17-33

    3. Angiogenesis in the female reproductive system

      • Hellmut G. Augustin
      Pages 35-52

    4. Arterialization, coronariogenesis and arteriogenesis

      • Borja Fernández
      Pages 53-63

    5. Sprouting angiogenesis versus co-option in tumor angiogenesis

      • Robert M.W. de Waal, William P.J. Leenders
      Pages 65-76

    6. Hormones and the neovascularization process: role of angiotensin II

      • Jean-Sébastien Silvestre, Bernard I. Lévy
      Pages 77-93

    7. Can tumor angiogenesis be inhibited without resistance?

      • Kathy D. Miller, Christopher J. Sweeney, George W. Sledge Jr
      Pages 95-112

  3. Cellular and physical mechanisms of blood vessel growth

    1. Role of pericytes in vascular morphogenesis

      • Christer Betsholtz, Per Lindblom, Holger Gerhardt
      Pages 115-125

    2. Role of monocytes and macrophages in angiogenesis

      • Leni Moldovan, Nicanor I. Moldovan
      Pages 127-146

    3. Bone marrow-derived endothelial progenitor cells for neovascular formation

      • Hiromi Nishimura, Takayuki Asahara
      Pages 147-154

    4. Can angiogenesis be exercised?

      • Jalees Rehman
      Pages 155-161

    5. Angiogenesis — a self-adapting principle in hypoxia

      • Hugo H. Marti
      Pages 163-180

    6. Cellular mechanisms of arteriogenesis

      • Matthias Heil, Wolfgang Schaper
      Pages 181-191

    7. Balancing luminal size and smooth muscle proliferation — a key control point in atherosclerosis and arteriogenesis

      • Jürgen R. Sindermann, Keith L. March
      Pages 193-205

  4. Molecular mechanisms of angiogenesis

    1. The role of VEGF in the regulation of physiological and pathological angiogenesis

      • Napoleone Ferrara
      Pages 209-231

    2. The anti-inflammatory actions of angiopoietin-1

      • Gavin Thurston, John S. Rudge, Ella Ioffe, Nicholas Papadopoulos, Christopher Daly, Srilatha Vuthoori et al.
      Pages 233-245

    3. The hemostatic system in angiogenesis

      • Victor W.M. van Hinsbergh, Pieter Koolwijk, Klaas Hoekman
      Pages 247-266

    4. Signal transduction in angiogenesis

      • Ian Zachary
      Pages 267-300

  5. Back Matter

    Pages 301-321
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Keywords

About this book

Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Editors and Affiliations

  • Department of Cellular and Integrative Physiology, Indiana Center for Vascular Biology and Medicine, Indianapolis, USA

    Matthias Clauss

  • Institute of Pathology, University Clinic Carl Gustav Carus TU Dresden, Dresden, Germany

    Georg Breier

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