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The Hereditary Basis of Allergic Diseases

  • Book
  • © 2002

Overview

Editors:
  1. Stephen T. Holgate

    1. School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, UK

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  2. John W. Holloway

    1. School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, UK

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Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii
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  2. Heredity of allergy and asthma

    • Tarja Laitinen
    Pages 1-16

  3. Genome scans for asthma

    • Matthias Wjst
    Pages 17-27

  4. The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites

    • Carole Ober
    Pages 29-36

  5. Genetic regulation of specific IgE responsiveness

    • Nobuyuki Hizawa
    Pages 37-53

  6. Genetic variation at the HLA and TCR loci and the development of allergy and asthma

    • Adel H. Mansur
    Pages 55-83

  7. Chromosome 11q13, FcɛRlβ and atopic asthma

    • Chaker N. Adra, X.-Q. Mao, A. Yamasaki, P-S. Gao, Xing Yang, T. Shirakawa et al.
    Pages 85-93

  8. Genetic regulation of interleukin-13 production

    • Tineke C. T. M. van der Pouw Kraan, John W. Holloway, Lucien A. Aarden, Jaring S. van der Zee
    Pages 95-111

  9. The role of interleukin-9 and the interleukin-9 receptor gene candidates in asthma

    • Roy C. Levitt, Michael P McLane, Luigi Grasso, Nicholas C. Nicolaides
    Pages 113-124

  10. Genetics of the nitric oxide synthetic pathway in asthma

    • Hartmut Grasemann, Jeffrey M. Drazen
    Pages 125-136

  11. Genetic regulation of leukotriene production and activity

    • I. Sayers, A. P. Sampson
    Pages 137-166

  12. Genetics of asthma severity

    • Ladina Joos, Peter D. ParĂ©, Andrew J. Sandford
    Pages 167-176

  13. Back Matter

    Pages 177-181
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Keywords

About this book

Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.

Editors and Affiliations

  • School of Medicine IIR (Respiratory Cell and Molecular Biology) Division Southampton General Hospital, University of Southampton, Southampton, UK

    Stephen T. Holgate

  • School of Medicine Human Genetics and IIR (Respiratory Cell and Molecular Biology) Divisions, University of Southampton, Southampton, UK

    John W. Holloway

Bibliographic Information

  • Book Title: The Hereditary Basis of Allergic Diseases

  • Editors: Stephen T. Holgate, John W. Holloway

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/978-3-0348-8137-1

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2002

  • Hardcover ISBN: 978-3-7643-6402-1Published: 01 July 2002

  • Softcover ISBN: 978-3-0348-9452-4Published: 24 October 2012

  • eBook ISBN: 978-3-0348-8137-1Published: 06 December 2012

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: XII, 179

  • Topics: Pharmacy

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