Progress in Inflammation Research

The Hereditary Basis of Allergic Diseases

Editors: Holgate, Stephen T., Holloway, John W. (Eds.)

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About this book

Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.

Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-0348-8137-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase Institutional customers should get in touch with their account manager
Hardcover $159.99
price for USA in USD
Softcover $139.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
The Hereditary Basis of Allergic Diseases
Editors
  • Stephen T. Holgate
  • John W. Holloway
Series Title
Progress in Inflammation Research
Copyright
2002
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-8137-1
DOI
10.1007/978-3-0348-8137-1
Hardcover ISBN
978-3-7643-6402-1
Softcover ISBN
978-3-0348-9452-4
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XII, 179
Topics