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Macrolide Antibiotics

  • Book
  • © 2002

Overview

Editors:
  1. Wolfgang Schönfeld

    1. PLIVA Research Antiinfective Research, Zagreb, Croatia

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    You can also search for this editor in PubMed   Google Scholar

  2. Herbert A. Kirst

    1. Elanco Animal Health Research & Development, Greenfield, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-X
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  2. Introduction to the macrolide antibiotics

    • Herbert A. Kirst
    Pages 1-13

  3. Macrolides: a clinical overview

    • Vito R. Iacoviello, Stephen H. Zinner
    Pages 15-24

  4. Pharmacokinetics/pharmacodynamics of macrolides

    • Holly M. Mattoes, Charles H. Nightingale
    Pages 25-36

  5. Cellular accumulation of macrolide antibiotics. Intracellular bioactivity

    • Marie-Thérèse Labro
    Pages 37-52

  6. Clarithromycin and new derivatives of erythromycin

    • Takashi Adachi, Shigeo Morimoto
    Pages 53-72

  7. Azithromycin and novel azalides

    • Wolfgang Schönfeld, Stjepan Mutak
    Pages 73-95

  8. Ketolides: novel antibacterial agents designed to overcome resistance to erythromycin A within gram-positive cocci

    • André Bryskier, Alexis Denis
    Pages 97-140

  9. Novel macrolide derivatives active against resistant pathogens

    • Ly T. Phan, Zhenkun Ma
    Pages 141-155

  10. Polyketide diversity

    • Leonard Katz
    Pages 157-175

  11. Biosynthesis of the macrolide antibiotic, tylosin

    • Eric Cundliffe
    Pages 177-184

  12. In vitro activity of macrolides against traditional susceptible bacteria

    • Adel Ben Ali, Fred W. Goldstein, Jacques F. Acar
    Pages 185-200

  13. Activity of macrolides against mycobacteria

    • Lowell S. Young, Luiz E. Bermudez
    Pages 201-213

  14. Chlamydia pneumoniae and asthma and atherosclerosis: role of macrolides

    • Margaret R. Hammerschlag
    Pages 215-228

  15. Activity of macrolides in sexually transmitted diseases

    • Geoffrey L. Ridgway
    Pages 229-241

  16. Helicobacter pylori and macrolides

    • Francis Mégraud
    Pages 243-260

  17. Effects of macrolide antibiotics on ribosome function

    • Norris E. Allen
    Pages 261-280

  18. Mechanisms of resistance to macrolides, lincosamides, and ketolides

    • Joyce A Sutcliffe, Roland Leclercq
    Pages 281-317

  19. Back Matter

    Pages 319-323
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Keywords

About this book

There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery­ thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy­ cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro­ lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro­ lactone structures, giving historic background, basic structure-activity relation­ ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.

Editors and Affiliations

  • PLIVA Research Antiinfective Research, Zagreb, Croatia

    Wolfgang Schönfeld

  • Elanco Animal Health Research & Development, Greenfield, USA

    Herbert A. Kirst

Bibliographic Information

  • Book Title: Macrolide Antibiotics

  • Editors: Wolfgang Schönfeld, Herbert A. Kirst

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-8105-0

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2002

  • Hardcover ISBN: 978-3-7643-6186-0Published: 01 March 2002

  • Softcover ISBN: 978-3-0348-9438-8Published: 23 October 2012

  • eBook ISBN: 978-3-0348-8105-0Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: X, 323

  • Topics: Pharmacology/Toxicology, Infectious Diseases, Immunology, Medical Microbiology

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