Progress in Inflammation Research

Cytokines in Severe Sepsis and Septic Shock

Editors: Redl, H. (Ed.)

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About this book

t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition­ ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin­ ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon­ stration of microorganisms in the circulation has led to a new definition and under­ standing of sepsis, mainly as the systemic response of the host to an often unde­ tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram­ positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap­ ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera­ peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Endotoxin as an inducer of cytokines

    Pages 3-13

    Schade, F. Ulrich (et al.)

  • Acute lung inflammation in septic shock of the cytokine release induced by bacterial superantigens

    Pages 15-36

    Neumann, Brigitte (et al.)

  • Lipopolysaccharide signaling pathways and their role in the development of the systemic inflammatory response syndrome

    Pages 37-56

    Hackam, David J. (et al.)

  • Predisposing factors: effect of sex, nutritional factors and age on immunity following shock and sepsis

    Pages 57-77

    Zellweger, René (et al.)

  • Genetics: cytokine polymorphisms

    Pages 79-92

    Stüber, Frank

Buy this book

eBook $169.00
price for USA in USD
  • ISBN 978-3-0348-8755-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $339.00
price for USA in USD
  • ISBN 978-3-7643-5877-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $219.99
price for USA in USD
  • ISBN 978-3-0348-9759-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Cytokines in Severe Sepsis and Septic Shock
Editors
  • H. Redl
Series Title
Progress in Inflammation Research
Copyright
1999
Publisher
Birkhäuser Basel
Copyright Holder
Springer Basel AG
eBook ISBN
978-3-0348-8755-7
DOI
10.1007/978-3-0348-8755-7
Hardcover ISBN
978-3-7643-5877-8
Softcover ISBN
978-3-0348-9759-4
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XX, 372
Topics