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Mechanisms of Secondary Brain Damage

Current State

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Alexander Baethmann

    1. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

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  2. Oliver Kempski

    1. Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany

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  3. Ludwig Schürer

    1. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

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Part of the book series: Acta Neurochirurgica Supplement (NEUROCHIRURGICA, volume 57)

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Table of contents (23 papers)

  1. Front Matter

    Pages I-VIII
    Download chapter PDF

  2. Brain Damage Studied by NMR and Other Methods

    1. NMR Spectroscopy: Current Status and Future Possibilities

      • David G. Gadian, S. R. Williams, T. E. Bates, R. A. Kauppinen
      Pages 1-8

    2. Cerebral Metabolic Studies in vivo by Combined 1H/31P and 1H/13C NMR Spectroscopic Methods

      • Kevin L. Behar
      Pages 9-20

    3. NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia

      • K.-A. Hossmann, K. L. Behar, D. L. Rothman
      Pages 21-29

    4. Magnetite as a Potent Contrast-Enhancing Agent in Magnetic Resonance Imaging to Visualize Blood-Brain Barrier Disruption

      • J. W. M. Bulte, M. W. A. de Jonge, R. L. Kamman, F. Zuiderveen, T. H. The, L. de Leij et al.
      Pages 30-34

    5. Absent Recruitment of Capillaries in Brain Tissue Recovering from Stroke

      • A. Gjedde, H. Kuwabara
      Pages 35-40

    6. Quantification of Primary and Secondary Lesions in Severe Head Injury

      • D. I. Graham, J. H. Adams, D. Doyle, I. Ford, T. A. Gennarelli, A. E. Lawrence et al.
      Pages 41-48

    7. Traumatic Damage to the Nodal Axolemma: an Early, Secondary Injury

      • T. A. Gennarelli, R. Tipperman, W. L. Maxwell, D. I. Graham, J. H. Adams, A. Irvine
      Pages 49-52

    8. Morphometrical Evaluation of Triflusal in Brain Infarction

      • N. Heye, A. Campos, S. Sampaolo, J. Cervos-Navarro
      Pages 53-55

  3. Mediators and Antagonism in Secondary Brain Damage

    1. In vivo and in vitro Control of Acid-Base Regulation of Brain Cells During Ischemic and Selective Acidic Exposure

      • F. Plum
      Pages 57-63

    2. Mediators of Vascular and Parenchymal Mechanisms in Secondary Brain Damage

      • M. Wahl, L. Schilling, A. Unterberg, A. Baethmann
      Pages 64-72

    3. Glutamate Receptor Antagonists in Experimental Focal Cerebral Ischaemia

      • James McCulloch, E. Ozyurt, C. Kun Park, D. G. Nehls, G. M. Teasdale, D. I. Graham
      Pages 73-79

    4. Cerebral Protection by Adenosine

      • Peter Schubert, G. W. Kreutzberg
      Pages 80-88

    5. Effects of Acute Isotonic Saline Administration on Serum Osmolality, Serum Electrolytes, Brain Water Content and Intracranial Pressure

      • Hector E. James, S. Schneider
      Pages 89-93

    6. Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation

      • N. H. Diemer, F. F. Johansen, H. Benveniste, T. Bruhn, M. Berg, E. Valente et al.
      Pages 94-101

    7. Recovery of Brain Function Following Ischemia

      • Lindsay Symon
      Pages 102-109

    8. Systematic Development of Cerebral Resuscitation After Cardiac Arrest. Three Promising Treatments: Cardiopulmonary Bypass, Hypertensive Hemodilution, and Mild Hypothermia

      • P. Safar, F. Sterz, Y. Leonov, A. Radovsky, S. Tisherman, K. Oku
      Pages 110-121

  5. Emergency Care and Treatment in Acute Cerebral Insults

    1. Assessment of Emergency Care in Trauma Patients

      • B. Bouillon, M. Schweins, A. Lechleuthner, M. Vorweg, H. Troidl
      Pages 137-140
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Keywords

About this book

Great progress has been made in the understanding and prevention of secondary brain damage from acute cerebral disorders, such as trauma and ischemia. Advances may be concerned in particular with better organization and logistics of preclinical emergency care, including rapid arrival of well-trained medical staff on the scene of an accident and of transportation to a competent hospital. Nevertheless, it is a safe assumption that development of secondary brain damage from both intra- and extracranial causes still represents a major factor for the final outcome in severe head injury. Thus, exchanges of experiences and information between various disciplines involved with this important clinical problem - trauma still assumes the number one position as a cause of morbidity and mortality up to an age of 45 years - may provide a basis for in-depth analysis of remaining problems as well as of methods of their solution. This exactly is the purpose of the present publication on concepts and findings pertinent for the general subject of secondary brain damage from various experimental as well as clinical viewpoints. An internationally high-ranking group of experts has been contributing to this collection of reviews on cerebral trauma and ischemia and its adverse sequelae, including cerebral exploration by most modern technologies, such as NMR spectroscopy or PET scanning, among others.

Editors and Affiliations

  • Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  • Institut für Neurochirurgische Pathophysiologie, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany

    Oliver Kempski

  • Neurochirurgische Klinik, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Ludwig Schürer

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