The Interferon System

1. Front Matter

   Pages I-XII

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2. Introduction

   • William E. Stewart II

   Pages 1-12

3. Interferon Assays

   • William E. Stewart II

   Pages 13-26

4. Interferon Inducers

   • William E. Stewart II

   Pages 27-57

5. Induction Mechanisms

   • William E. Stewart II

   Pages 58-76

6. The Genetics of Interferon Production

   • William E. Stewart II

   Pages 77-89

7. Interferon Production

   • William E. Stewart II

   Pages 90-133

8. Interferons: Their Purification and Characterization

   • William E. Stewart II

   Pages 134-183

9. The Genetics of Interferon Action

   • William E. Stewart II

   Pages 184-195

10. Mechanisms of Antiviral Actions of Interferons

    • William E. Stewart II

    Pages 196-222

11. Non-Antiviral Actions of Interferons

    • William E. Stewart II

    Pages 223-256

12. Pharmacokinetics of Interferons

    • William E. Stewart II

    Pages 257-265

13. Antiviral Actions of Interferons in Animals

    • William E. Stewart II

    Pages 266-291

14. Antitumor Activities of Interferons in Animals

    • William E. Stewart II

    Pages 292-304

15. Interferon in the Clinic

    • William E. Stewart II

    Pages 305-321

16. Prelude to the Interferon System

    • William E. Stewart II

    Pages 322-323

17. Back Matter

    Pages 324-493

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This book is an update of Interferon, published in 1969 by Dr. Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor activities. The steadily increasing number of these non-antiviral functions of interferons emphasizes the need for a comprehensive - and critical - review of the entire literature of interferon studies. The text, with its supporting bibliography, provides complete coverage of interferon research. A newcomer to the area should find here all the informa­ tion necessary to understand why interferon, which has been studied for more than twenty years and which originally stirred excitement over its clinical pros­ pects, is still inspiring speculation about this potential. For those already fa­ miliar with the seemingly perpetual clinical promise of interferon, this volume should serve as a valuable reference source, the largest bibliography on the subject ever to appear under one cover. Clearly, this book should be considered only as an introduction to the topic and as a reference source; most questions about the interferon system are still unanswered - even unasked. Hopefully this summation and critical evalua­ tion of work done to date will stimulate and facilitate further progress.

• System
• interferon

• Interferon Laboratories, Sloan-Kettering Institute for Cancer Resarch, New York, USA

  William E. Stewart

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