Developmental Neuropathology

1. Front Matter

   Pages I-XII

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2. Gross and Microscopic Development of the Central Nervous System

   1. Gross and Microscopic Development of the Central Nervous System

      • Reinhard L. Friede

      Pages 1-23

3. Acquired Lesions in Newborns and Infants

   1. Hemorrhages Characteristic of Asphyxiated Premature Infants

      • Reinhard L. Friede

      Pages 24-37

   2. Cerebral Lesions from Physical Trauma

      • Reinhard L. Friede

      Pages 37-44

   3. Periventricular Infarcts

      • Reinhard L. Friede

      Pages 44-51

   4. Diffuse Fatty Change of White Matter

      • Reinhard L. Friede

      Pages 51-56

   5. Perinatal Lesions of Cerebral and Cerebellar Cortex

      • Reinhard L. Friede

      Pages 57-64

   6. Lesions of Basal Ganglia, Brain Stem and Cord

      • Reinhard L. Friede

      Pages 64-75

   7. Kernicterus (Bilirubin Encephalopathy)

      • Reinhard L. Friede

      Pages 75-85

   8. Various Topographic Patterns of Postnatal Neuron Loss

      • Reinhard L. Friede

      Pages 85-93

   9. Progressive Sclerosing Cortical Atrophy: Spongy Glio-Neuronal Dystrophy

      • Reinhard L. Friede

      Pages 93-102

   10. Porencephaly, Hydranencephaly, Multilocular Cystic Encephalopathy

       • Reinhard L. Friede

       Pages 102-122

   11. Arterial Occlusive Disease in Infancy

       • Reinhard L. Friede

       Pages 122-134

   12. Thrombosis of Intracranial Sinus and Veins

       • Reinhard L. Friede

       Pages 135-144

   13. Cerebral Lesions in Congenital Cardiac Disease

       • Reinhard L. Friede

       Pages 144-149

   14. Cranio-Cerebral Trauma in Infancy

       • Reinhard L. Friede

       Pages 150-153

   15. Fetal Infections

       • Reinhard L. Friede

       Pages 153-166

   16. Leptomeningitis in Newborns and Infants

       • Reinhard L. Friede

       Pages 166-178

   17. Meningoencephalitic Processes in the Perinatal Period

       • Reinhard L. Friede

       Pages 178-187

   18. Subdural Hematomas, Hygromas and Effusions

       • Reinhard L. Friede

       Pages 187-195

The present text was envisioned as a supplement to eXlstmg texts on human neuropathology, covering only those aspects of pediatric neuropathol­ ogy which pertain to and are peculiar of the immature nervous system. No coverage-or only brief comment-is given to diseases commonly found in adults which may, on occasion, occur in childhood or infancy as well. The subject matter is divided into three main categories: 1. The "acquired" lesions dating to the fetal, perinatal or early postnatal periods, 2. the malformations, and 3. the heritable metabolic defects. The first 6 chapters (2-7) are reserved to the lesions most intimately linked to the circumstances of birth. There is some inherent ambiguity in distinguishing between "acquired" lesions and malformations, as, indeed, no sharp distinction can be made between one and the other. Many malformations result from diseases acquired during fetal life and their peculiarity resides in the fact that the organ becomes affected before its development terminates and in such a way that its subsequent development becomes deranged or partly abrogated. A variety of causes acting at the same developmental period or over a common pathogenetic mechanism may produce the same type of derangement, including chemical, physical, infectious or genetic factors, as pointed out repeatedly in the text. Consequently, the definition of a malformation, as differing from an "acquired" residual lesion was made dependant on evidence for the derangement of developmental pro­ cesses subsequent to the acquisition of the disease.

• neuropathology

• Case Western Reserve University, Cleveland, USA

  Reinhard L. Friede

• University of Zurich, Switzerland

  Reinhard L. Friede

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