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Vaccine Analysis: Strategies, Principles, and Control

  • Book
  • © 2015

Overview

Editors:
  1. Brian K. Nunnally

    1. Apex, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Vincent E. Turula

    1. Pfizer BioTherapeutics Pharmaceutical Sc, Pearl River, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Robert D. Sitrin

    1. Sitrin Solutions, Lafayette Hill, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Equips readers to handle the complex analysis of vaccines

  • Treats both research and application aspects

  • Describes analytical and quality control technologies

  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Live Attenuated Viral Vaccines

    • Mark S. Galinski, Kuldip Sra, John I. Haynes II, Jennifer Naspinski
    Pages 1-44

  3. Inactivated Viral Vaccines

    • Barbara Sanders, Martin Koldijk, Hanneke Schuitemaker
    Pages 45-80

  4. Recombinant Virus-like Particle Protein Vaccines

    • Robert D. Sitrin, Qinjian Zhao, Clinton S. Potter, Bridget Carragher, Michael W. Washabaugh
    Pages 81-112

  5. Analysis of Influenza Vaccines

    • Pierre-Alain Moisset, Jeffrey Pederson, Nathalie Landry
    Pages 113-137

  6. Live-Attenuated and Inactivated Whole-Cell Bacterial Vaccines

    • Anita H. J. van den Biggelaar, Jan T. Poolman
    Pages 139-186

  7. Analytical Control Strategy of Bacterial Subunit Vaccines

    • Shwu-Maan Lee, Vincent Turula, Bradford Powell, Mikkel Nissum, Mariagrazia Pizza, Claudia Magagnoli et al.
    Pages 187-270

  8. Bacterial Polysaccharide Vaccines: Analytical Perspectives

    • Earl Zablackis, Philippe Talaga, Suddham Singh
    Pages 271-299

  9. Glycoconjugate Vaccines

    • Neil Ravenscroft, Paolo Costantino, Philippe Talaga, Roberto Rodriguez, William Egan
    Pages 301-381

  10. Vaccines in Research and Development: New Production Platforms and New Biomolecular Entities for New Needs

    • John P. Hennessey Jr., Niranjan Y. Sardesai
    Pages 383-396

  11. Role of Analytics in Viral Safety

    • Rebecca L. Sheets, Paul A. Duncan
    Pages 397-443

  12. Deep Sequencing Applications for Vaccine Development and Safety

    • David Onions, Colette Côté, Brad Love, John Kolman
    Pages 445-477

  13. Quality-by-Design: As Related to Analytical Concepts, Control and Qualification

    • Beth Junker, Earl Zablackis, Thorsten Verch, Tim Schofield, Pierre Douette
    Pages 479-520

  14. Vaccine Potency Assays

    • Todd Ranheim, Ned Mozier, William Egan
    Pages 521-541

  15. Establishing a Shelf Life and Setting Lot-Release Specifications

    • William Egan, Timothy Schofield
    Pages 543-562

  16. Vaccine Reference Standards

    • Brian K. Nunnally
    Pages 563-572

  17. Lot Release of Vaccines by Regulatory Authorities and Harmonization of Testing Requirements

    • Rajesh K. Gupta, Chander K. Gupta, Laurent Mallet
    Pages 573-596

  18. Dendritic Cell Targeting Vaccines

    • Yoonkyung Do, Bradford Powell
    Pages 597-659

  19. Back Matter

    Pages 661-665
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Keywords

About this book

This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities.

Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.

Editors and Affiliations

  • Apex, USA

    Brian K. Nunnally

  • Pfizer BioTherapeutics Pharmaceutical Sc, Pearl River, USA

    Vincent E. Turula

  • Sitrin Solutions, Lafayette Hill, USA

    Robert D. Sitrin

Bibliographic Information

  • Book Title: Vaccine Analysis: Strategies, Principles, and Control

  • Editors: Brian K. Nunnally, Vincent E. Turula, Robert D. Sitrin

  • DOI: https://doi.org/10.1007/978-3-662-45024-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-662-45023-9Published: 09 December 2014

  • Softcover ISBN: 978-3-662-52266-0Published: 10 September 2016

  • eBook ISBN: 978-3-662-45024-6Published: 27 November 2014

  • Edition Number: 1

  • Number of Pages: XII, 665

  • Number of Illustrations: 48 b/w illustrations, 76 illustrations in colour

  • Topics: Vaccine, Immunology, Medical Biochemistry

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