Overview
- First comprehensive and up-to-date overview on mouse genetics since the mid-nineties
- Essential reading for scientists working in mouse research
- Written by experienced geneticists
- Includes supplementary material: sn.pub/extras
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About this book
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.
The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.
In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
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Keywords
Table of contents (10 chapters)
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Front Matter
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Back Matter
Authors and Affiliations
Bibliographic Information
Book Title: Genetics of the Mouse
Authors: Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
DOI: https://doi.org/10.1007/978-3-662-44287-6
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2015
Hardcover ISBN: 978-3-662-44286-9Published: 09 December 2014
Softcover ISBN: 978-3-662-51016-2Published: 11 September 2016
eBook ISBN: 978-3-662-44287-6Published: 29 November 2014
Edition Number: 1
Number of Pages: XVII, 408
Number of Illustrations: 62 b/w illustrations, 44 illustrations in colour
Topics: Animal Genetics and Genomics, Animal Models, Transgenics, Gene Expression, Genetic Engineering