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Metronomic Chemotherapy

Pharmacology and Clinical Applications

  • Book
  • © 2014

Overview

Editors:
  1. Guido Bocci

    1. Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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  2. Giulio Francia

    1. Department of Biological Sciences, University of Texas at El Paso, El Paso, USA

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  • Covers all aspects of metronomic chemotherapy

  • Describes the pharmacological bases of metronomic chemotherapy

  • Presents and discusses the clinical results of all published studies on metronomic chemotherapy, in a wide range of tumors

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Pharmacological Bases of Metronomic Chemotherapy

    1. Front Matter

      Pages 1-1
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    2. Development and Evolution of the Concept of Metronomic Chemotherapy: A Personal Perspective

      • Robert S. Kerbel
      Pages 3-21

    3. Mechanisms of Action of Low-Dose Metronomic Chemotherapy

      • Ella Fremder, Yuval Shaked
      Pages 23-38

    4. Effects of Metronomic Chemotherapy on Immunity

      • Mamoru Harada
      Pages 39-51

    5. Preclinical Activity of Metronomic Regimens with Alkylating Agents and Antimetabolites

      • Marta Vives, Berta Laquente, Francesc Viñals
      Pages 53-67

    6. Metronomic Chemotherapy Regimens Using Microtubule-Targeting Agents: Mechanisms of Action, Preclinical Activity and Future Developments

      • Eddy Pasquier, Maria Kavallaris, Nicolas Andre
      Pages 69-90

  3. Clinical Activity of Metronomic Chemotherapy

    1. Front Matter

      Pages 91-91
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    2. Metronomic Chemotherapy in Breast Cancers

      • Elisabetta Munzone, Francesco Bertolini, Marco Colleoni
      Pages 93-110

    3. Overview of Metronomic Chemotherapy in SWOG Breast Cancer Cooperative Group Clinical Trials

      • Zeina A. Nahleh
      Pages 111-118

    4. Clinical Trials of Low-Dose Metronomic Chemotherapy in Castration-Resistant Prostate Cancer

      • Keemo Delos Santos, Lavarnan Sivanathan, Kelly Lien, Urban Emmenegger
      Pages 119-134

    5. The Role of Metronomic Chemotherapy in the Treatment of Metastatic Colorectal Cancer Patients

      • Lisa Salvatore, Federica Zoratto, Fotios Loupakis, Alfredo Falcone
      Pages 135-142

    6. Clinical Activity of Metronomic Chemotherapy in Central Nervous System Cancers

      • Doo-Sik Kong, Do-Hyun Nam
      Pages 143-155

    7. Metronomic Chemotherapy in Pediatric Malignancies

      • Narges Baluch, Sushil Kumar, Reza Mokhtari, Sylvain Baruchel
      Pages 157-172

    8. Metronomic Chemotherapy in Hematological Malignancies

      • Pannee Praditsuktavorn, Jia Ruan
      Pages 173-188

    9. Clinical Activity of Metronomic Chemotherapy in Liver Cancers

      • Yu-Yun Shao, Ann-Lii Cheng, Chih-Hung Hsu
      Pages 189-202

    10. Metronomic Chemotherapy in Gynecological Cancers

      • Victoria A. Forte, Agustin A. Garcia
      Pages 203-216

    11. Metronomic Chemotherapy in Non-Small-Cell Lung Cancer

      • Athanasios Kotsakis, Nikolaos Kentepozidis, Vassilis Georgoulias
      Pages 217-226

  4. Clinical Pharmacology of Metronomic Chemotherapy

    1. Front Matter

      Pages 227-227
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    2. Pharmacokinetics and Pharmacogenetics of Metronomic Chemotherapy

      • Guido Bocci, Giulio Francia
      Pages 229-246
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Keywords

About this book

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Editors and Affiliations

  • Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

    Guido Bocci

  • Department of Biological Sciences, University of Texas at El Paso, El Paso, USA

    Giulio Francia

Bibliographic Information

  • Book Title: Metronomic Chemotherapy

  • Book Subtitle: Pharmacology and Clinical Applications

  • Editors: Guido Bocci, Giulio Francia

  • DOI: https://doi.org/10.1007/978-3-662-43604-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-662-43603-5Published: 26 September 2014

  • Softcover ISBN: 978-3-662-51319-4Published: 22 September 2016

  • eBook ISBN: 978-3-662-43604-2Published: 04 September 2014

  • Edition Number: 1

  • Number of Pages: XVI, 295

  • Number of Illustrations: 9 b/w illustrations, 13 illustrations in colour

  • Topics: Pharmacology/Toxicology, Oncology, Cancer Research

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