Reviews of Physiology, Biochemistry and Pharmacology

1. Front Matter

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2. Phospholipase D—Structure, regulation and function

   • J. H. Exton

   Pages 1-94

3. Endotoxin tolerance — Mechanisms and beneficial effects in bacterial infection

   • M. D. Lehner, T. Hartung

   Pages 95-141

4. The structural basis of g-protein-coupled receptor function and dysfunction in human diseases

   • T. Schöneberg, A. Schulz, T. Gudermann

   Pages 144-227

In this volume of Reviews there are three outstanding articles, one on phspholipase D, an enzyme that is widely distributed in bacteria, protozoa, fungi, plants and animals. Phospholipase D carries out a transphosphatidylation reaction, which is unique to this enzyme. This review is focussed on mammalian PLDs. The second review deals with endotoxin tolerance, the term which describes the phenomenon that immune responses and metabolic changes are mitigated after repeated LPS administration. The third article summarizes the current knowledge relevant to understanding the molecular basis of GPCR function and focusses on the underlying mechanisms of GPCR malfunctions responsible for diferent human diseases.

• Endotoxin
• G-protein-coupled receptors
• GPCR
• LPS
• PLD
• immune response
• phospholipase
• transmembrane receptors
• transphosphatidylation reaction
• bacteria
• biochemistry
• enzyme
• enzymes
• membrane receptor
• pharmacology
• physiology
• protein
• receptor
• research

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