Medical Intelligence Unit

c-Myc Function in Neoplasia

Authors: Dang, C.V., Lee, Linda A.

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About this book

1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib­ A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil­ ity to dissect many biological processes at the molecular level. Most spectacular is the technology of molecular biology that allows identi­ fication and characterization of genes that participate in the genesis of human cancers. Three major groups of genes appear to play out the drama of cancer development: tumor suppressor genes, mis­ match repair genes, and oncogenes. The tumor suppressor genes 1 encode products that are inhibitory to cell proliferation. The loss of these inhibitors, by mutation or deletion, can unleash cells from their restraints to proliferate. Mutations in the mismatch repair 2 10 genes also have been implicated in tumorigenesis. - The inability of cells to repair spontaneously occurring mutations leads to genom­ ic instability and could potentially result in the accumulation of car­ cinogenic DNA lesions. Finally, activation of proto-oncogenes, which are normal cellular genes, into oncogenes could accelerate the 11 processes of cell proliferation. c-myc was one of the very first proto­ oncogenes to be identified and because it normally plays pivotal roles in both cell proliferation and cell death has enticed many to investigate the molecular mechanisms by which it transforms cells.

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-662-22681-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-662-22683-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
c-Myc Function in Neoplasia
Authors
Series Title
Medical Intelligence Unit
Copyright
1995
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
Distribution Rights
Distribution rights for the USA, Canada and Mexico: R.G. Landes, Biomedical Publishers
eBook ISBN
978-3-662-22681-0
DOI
10.1007/978-3-662-22681-0
Softcover ISBN
978-3-662-22683-4
Series ISSN
1080-3645
Edition Number
1
Number of Pages
IX, 201
Number of Illustrations
33 b/w illustrations
Additional Information
Jointly published with R.G. Landes, Biomedical Publishers, Austin, USA
Topics