Mitochondrial DNA Mutations in Aging, Disease and Cancer
Editors: Singh, Keshav K. (Ed.)
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- About this book
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Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.
- Table of contents (20 chapters)
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Introduction
Pages 1-15
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Mitochondrial Structure, Function and Biogenesis
Pages 17-41
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The Mitochondrial Genetic System
Pages 43-83
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Inheritance of Mitochondrial Mutations
Pages 85-99
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Mitochondrial DNA Replication
Pages 101-114
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Table of contents (20 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Mitochondrial DNA Mutations in Aging, Disease and Cancer
- Editors
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- Keshav K. Singh
- Copyright
- 1998
- Publisher
- Springer-Verlag Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- eBook ISBN
- 978-3-662-12509-0
- DOI
- 10.1007/978-3-662-12509-0
- Softcover ISBN
- 978-3-662-12511-3
- Edition Number
- 1
- Number of Pages
- XX, 412
- Number of Illustrations
- 42 b/w illustrations, 6 illustrations in colour
- Additional Information
- Jointly published with Landes Bioscience, Georgetown, USA
- Topics
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