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Ernst Schering Foundation Symposium Proceedings

Pharmacokinetic Challenges in Drug Discovery

Editors: Pelkonen, O., Baumann, A., Reichel, A. (Eds.)

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  • ISBN 978-3-662-04383-7
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About this book

Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Accelerating the Process of Drug Discovery

    Pages 1-32

    Davis, A. M. (et al.)

  • The Role of Pharmacokinetics in Drug Discovery: Finding Drug Candidates with the Greatest Potential for Success

    Pages 33-47

    Lin, J. H.

  • Rapid Permeability Screening in Drug Discovery to Predict Human Intestinal Absorption

    Pages 49-67

    Mannens, G. S. J. (et al.)

  • Drug Metabolism Assays and Their Use in Drug Discovery

    Pages 69-79

    Bayliss, M. K. (et al.)

  • Prediction of Human Pharmacokinetics Based on Preclinical In Vitro and In Vivo Data

    Pages 81-104

    Lavé, T. (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-662-04383-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $219.99
price for USA in USD
  • ISBN 978-3-662-04385-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pharmacokinetic Challenges in Drug Discovery
Editors
  • O. Pelkonen
  • A. Baumann
  • A. Reichel
Series Title
Ernst Schering Foundation Symposium Proceedings
Series Volume
37
Copyright
2002
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-662-04383-7
DOI
10.1007/978-3-662-04383-7
Softcover ISBN
978-3-662-04385-1
Series ISSN
0947-6075
Edition Number
1
Number of Pages
XIV, 306
Number of Illustrations
29 b/w illustrations
Topics