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Pharmacokinetic Challenges in Drug Discovery

  • Conference proceedings
  • © 2002

Overview

Editors:
  1. O. Pelkonen

    1. Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finnland

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  2. A. Baumann

    1. Research Pharmacokinetics, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. A. Reichel

    1. Research Pharmacokinetics, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 37)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XIV
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  2. Accelerating the Process of Drug Discovery

    • A. M. Davis, J. Dixon, C. J. Logan, D. W. Payling
    Pages 1-32

  3. The Role of Pharmacokinetics in Drug Discovery: Finding Drug Candidates with the Greatest Potential for Success

    • J. H. Lin
    Pages 33-47

  4. Rapid Permeability Screening in Drug Discovery to Predict Human Intestinal Absorption

    • G. S. J. Mannens, H. Bohets, P. Verboven, K. Steemans, K. Lavrijsen, W. Meuldermans
    Pages 49-67

  5. Drug Metabolism Assays and Their Use in Drug Discovery

    • M. K. Bayliss, P. J. Eddershaw
    Pages 69-79

  6. Prediction of Human Pharmacokinetics Based on Preclinical In Vitro and In Vivo Data

    • T. Lavé, O. Luttringer, J. Zuegge, G. Schneider, P. Coassolo, F.-P. Theil
    Pages 81-104

  7. In Vitro Screening of Cytochrome P450 Induction Potential

    • O. Pelkonen, J. Hukkanen, P. Honkakoski, J. Hakkola, P. Viitala, H. Raunio
    Pages 105-137

  8. Drug Transport Across the Blood-Brain Barrier

    • G. Fricker
    Pages 139-154

  9. The Development and Implementation of Bioanalytical Methods Using LC-MS to Support ADME Studies in Early Drug Discovery and Candidate Selection

    • T. V. Olah
    Pages 155-183

  10. Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening

    • A. K. Mandagere
    Pages 185-202

  11. High-Throughput Screening — Brains Versus Brawn

    • D. A. Smith
    Pages 203-212

  12. Relation of Molecular Properties with Drug Absorption and Disposition

    • H. van de Waterbeemd
    Pages 213-234

  13. Modelling Human Cytochrome P450-Substrate Interactions

    • D. F. V. Lewis
    Pages 235-248

  14. Forum Discussion: ADME-Based Compound Optimization and Selection Paradigm

    • Andreas Baumann, Martin Bayliss, Thorsten Blume, Ulf Boemer, Gerardine Burton, Gabriele Cruziani et al.
    Pages 249-298

  15. Back Matter

    Pages 299-306
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Keywords

About this book

Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.

Editors and Affiliations

  • Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finnland

    O. Pelkonen

  • Research Pharmacokinetics, Schering AG, Berlin, Germany

    A. Baumann, A. Reichel

Bibliographic Information

  • Book Title: Pharmacokinetic Challenges in Drug Discovery

  • Editors: O. Pelkonen, A. Baumann, A. Reichel

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-04383-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2002

  • Softcover ISBN: 978-3-662-04385-1Published: 16 December 2012

  • eBook ISBN: 978-3-662-04383-7Published: 09 March 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XIV, 306

  • Number of Illustrations: 29 b/w illustrations

  • Topics: Pharmacology/Toxicology, Biochemistry, general

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