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Of Fish, Fly, Worm, and Man

Lessons from Developmental Biology for Human Gene Function and Disease

  • Conference proceedings
  • © 2000

Overview

Editors:
  1. Christiane Nüsslein-Volhard

    1. Abteilung Genetik, Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany

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  2. Jörn Krätzschmar

    1. Enabling Technologies, Preclinical Drug Research, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 29)

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Table of contents (12 papers)

  1. Front Matter

    Pages I-XV
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  2. Interactions Between Wingless and Frizzled Molecules in Drosophila

    • R. Nusse, E. Rulifson, M. Fish, C. Harryman-Samos, M. Brink, C-h. Wu et al.
    Pages 1-11

  3. The Heterotrimeric G Protein Genes of Caenorhabditis elegans

    • G. Jansen, K. L. Thijssen, P. Werner, M. van der Horst, E. Hazendonk, R. H. A. Plasterk
    Pages 13-34

  4. Programmed Cell Death and Its Regulation and Initiation in C. elegans

    • B. Conradt
    Pages 35-55

  5. Presenilin Proteins and Their Function During Embryonic Development and Alzheimer’s Disease

    • C. Haass
    Pages 57-64

  6. Cell—Cell Interaction During Drosophila Embryogenesis: Novel Mechanisms and Molecules

    • M. Affolter
    Pages 65-79

  7. The Roles of BMPs, BMP Antagonists, and the BMP Signaling Transducers Smad1 and Smad5 During Dorsoventral Patterning of the Zebrafish Embryo

    • M. Hild, A. Dick, H. Bauer, S. Schulte-Merker, P. Haffter, T. Bouwmeester et al.
    Pages 81-106

  8. Genetic Dissection of Heart Development

    • J.-N. Chen, M. C. Fishman
    Pages 107-122

  9. Eph Receptors and Ephrins Are Key Regulators of Morphogenesis

    • N. Holder, L. Durbin, J. Cooke, Stephen Wilson
    Pages 123-149

  10. Eph Receptor Tyrosine Kinases and Their Ligands in Development

    • U. Drescher
    Pages 151-164

  11. Embryonic Patterning of Xenopus Mesoderm by Bmp-4

    • C. Niehrs, R. Dosch, D. Onichtchouk
    Pages 165-190

  12. The Indian Hedgehog — PTHrP System in Bone Development

    • A. Vortkamp
    Pages 191-209

  13. Hedgehog Signaling in Animal Development and Human Disease

    • E. C. Bailey, M. P. Scott, R. L. Johnson
    Pages 211-235

  14. Back Matter

    Pages 237-243
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Keywords

About this book

The first complete genome sequence of a multicellular organism, Caenorhabditis elegans, has been determined recently. Several more will follow soon, among them the genome sequences of Drosophila melanogaster and the human. With these achievements, the stage is set for the next phase of "large-scale" biology, the study of the function of genes and the interactions between their protein products. The aim of the Ernst Schering Research Foundation Workshop 29 was to discuss the contribution of research on model organisms which are particularly suited for genetic and biological research, to the understanding of gen­ eral principles of biology as well as the basis for human diseases. This area of research has not only unveiled the basic molecular mechanisms of development of higher organisms, but has also made major contri­ butions to the elucidation of complex signal transduction pathways that play crucial roles both in ontogeny and human diseases. Establishing the complete molecular anatomy of an organism is a demanding but rather well-defined task. However, compared to the technical and scientific challenges of large-scale sequencing and the bioinformatics analysis of complete genome data, the assignment of function to the genes of multicellular organisms may still seem like a fishing expedition, with no universal road to success. One approach is based on large-scale technologies. The use of mi­ croarrays for multiple gene expression analysis is one element in this effort, providing important information on the cell- or tissue-specific activation of genes over time.

Editors and Affiliations

  • Abteilung Genetik, Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany

    Christiane Nüsslein-Volhard

  • Enabling Technologies, Preclinical Drug Research, Schering AG, Berlin, Germany

    Jörn Krätzschmar

Bibliographic Information

  • Book Title: Of Fish, Fly, Worm, and Man

  • Book Subtitle: Lessons from Developmental Biology for Human Gene Function and Disease

  • Editors: Christiane Nüsslein-Volhard, Jörn Krätzschmar

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-04264-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Softcover ISBN: 978-3-662-04266-3Published: 03 December 2012

  • eBook ISBN: 978-3-662-04264-9Published: 14 March 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XV, 243

  • Number of Illustrations: 83 b/w illustrations

  • Topics: Microbiology, Cell Biology, Molecular Medicine

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