Molecular Mechanisms of Membrane Traffic

1. Front Matter

   Pages I-XIII

   PDF

2. Endoplasmic Reticulum, Structure, Function and Transport to Golgi Complex

   1. Cell-Free Analysis of ER to Golgi Apparatus Vesicular Traffic

      • D. James Morré, D. M. Morré

      Pages 1-15

   2. Identification of a Novel Post-ER, Pre-Golgi Compartment Where Unassembled Monomers of Oligomeric Proteins Accumulate

      • T. C. Hobman, L. Woodward, M. Komuro, M. G. Farquhar

      Pages 17-34

   3. G Protein Regulation of Vesicular Transport Through the Exocytic Pathway

      • W. E. Balch, H. Plutner, R. Schwaninger, E. J. Tisdale, H. W. Davidson, J. Bourne et al.

      Pages 35-44

   4. Fusion Rapidly Follows Vesicle Transport to the Target Membrane in Protein Transport through the Golgi Apparatus in Vitro. A Re-evaluation of Transport Kinetics Based on the Finding that the Glycosylation Used to Mark Transport, and Not Transport Itself, is Rate Limiting in the Assay

      • R. R. Hiebsch, B. W. Wattenberg

      Pages 45-51

   5. Immunocytochemical analysis of the transfer of vesicular stomatitis virus G glycoprotein from the intermediate compartment to the Golgi complex

      • S. Bonatti, L. V. Lotti, M. R. Torrisi, M. C. Pascale

      Pages 53-54

   6. Synthesis of Glycosyl-Phosphatidylinositol Anchors is Initiated in the Endoplasmic Reticulum

      • J. Vidugiriene, A. K. Menon

      Pages 55-56

   7. Protein Trafficking along the Exocytotic Pathway

      • Wanjin Hong

      Pages 57-58

   8. A Short N-Terminal Sequence is Responsible for the Retention of Invariant Chain (Ii) in the Endoplasmic Reticulum

      • Marie-Paule Schutze, Michael R. Jackson, Per A. Peterson

      Pages 59-60

   9. Isolation and characterization of the principal ATPase of transitional elements of the endoplasmic reticulum of rat liver

      • L. Zhang, D. J. Morré

      Pages 61-62

   10. A GTP Hydrolase Activity Purified from Transitional Endoplasmic Reticulum of Rat Liver Binds Retinol

       • J. Zhao, D. M. Morré

       Pages 63-64

   11. A 38 kDa Protein Resident to CIS Golgi Apparatus Cisternae of Rat Liver is Recognized by an Antibody Directed Against α Subunits of Trimeric G-Proteins

       • A. O. Brightman, M. Paulik, J. B. Lawrence, T. Reust, C. C. Geilen, K. Spicher et al.

       Pages 65-66

   12. Acyl Transfer Reactions Associated with Cis Golgi Apparatus

       • J. B. Lawrence, T. W. Keenan, P. Moreau, D. J. Morré

       Pages 67-68

   13. Hepatic Bile Formation: Intracellular Trafficking of Bile Salts

       • James M. Crawford, Stephen Barnes, Rebecca C. Stearns, Cynthia L. Hastings, Deborah C. J. Strahs, John J. Godleski

       Pages 69-70

   14. Wheat storage proteins as a model system to study the mechanism of protein sorting within the endoplasmic reticulum

       • Gad Galili, Yoram Altschuler

       Pages 71-72

3. Import into Mitochondria, Peroxisomes, Chloroplasts and Vacuoles

   1. Determinants of Outer Membrane Protein Sorting and Topology in Mitochondria

      • G. C. Shore, H. M. McBride, D. G. Millar, J.-M. Li

      Pages 73-79

   2. Molecular Chaperones HSP70 and HSP60 in Protein Folding and Membrane Translocation

      • Jörg Martin, F.-Ulrich Hartl

      Pages 81-90

   3. Cytosolic Reactions in Mitochondrial Protein Import

      • Douglas M. Cyr, Michael G. Douglas

      Pages 91-94

   4. Human Bifunctional Enzyme and Its Import into Peroxisomes

      • G. L. Chen, M. C. McGuinness, G. Hoefler, A. B. Moser

      Pages 95-98

   5. Transport of Microinjected Proteins into the Peroxisomes of Mammalian Cells

      • P. A. Walton, S. J. Gould, S. Subramani

      Pages 99-100

The study of membrane traffic in reconstituted cell-free systems has generated an unprecedented amount of new information on the biochemistry, molecular biology and genetics of membrane-based molecular events that underly normal and abnormal cellular function. Many of the individual steps have now been isolated and dissected in simple systems that permit detailed molecular analyses of transport mechanisms and their regulation. Reconstituted events of intercompartment transport include inter-membrane recognition, and controlled membrane fusion-fission reactions. Among the many advances is the growi ng awareness of a remarkabl e evolutionary conservation of many of the components involved in the many steps of membrane traffic, this realization has accelerated greatly the pace of progress in the field. This book provides a collection of participant contributions from the 1992 Summer Research Conference, "Mol ecul ar Mechani sms of Membrane Traffi c, " jointly sponsored with NATO by the American Society of Cell Biology. The conference was held May 9-13, at the Airlie Conference Center in the Virginia countryside, near Warrenton. The conference was attended by 158 scientists. A unique feature was the high proportion of young scientists among the participants. Approximately 65% were students, postdoctoral fe 11 ows and young investigators. Each attendee contri buted to the conference with either a pl atform or poster presentation.

• Chloroplast
• Nucleotide
• biochemistry
• biology
• enzyme
• membrane
• membrane transport
• molecular biology
• molecular mechanisms
• morphology
• protein
• proteins
• protoplasts
• regulation
• translation

• Department of Medicinal Chemistry, HANS Life Science Research Building, Purdue University, West Lafayette, USA

  D. James Morré

• C & S Biology, School of Medicine University of Colorado, Denver, USA

  Kathryn E. Howell

• Department of Anatomy and Cell Biology, McGill University, Montreal, Canada

  John J. M. Bergeron

Policies and ethics