BestMasters

Predicting the Lineage Choice of Hematopoietic Stem Cells

A Novel Approach Using Deep Neural Networks

Authors: Kroiss, Manuel

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  • Publication in the Field of Organic Chemistry 

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  • ISBN 978-3-658-12879-1
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About this book

Manuel Kroiss examines the differentiation of hematopoietic stem cells using machine learning methods. This work is based on experiments focusing on the lineage choice of CMPs, the progenitors of HSCs, which either become MEP or GMP cells. The author presents a novel approach to distinguish MEP from GMP cells using machine learning on morphology features extracted from bright field images. He tests the performance of different models and focuses on Recurrent Neural Networks with the latest advances from the field of deep learning. Two different improvements to recurrent networks were tested: Long Short Term Memory (LSTM) cells that are able to remember information over long periods of time, and dropout regularization to prevent overfitting. With his method, Manuel Kroiss considerably outperforms standard machine learning methods without time information like Random Forests and Support Vector Machines.

About the authors

After finishing his MSc in Bioinformatics, Manuel Kroiss moved to London to work for a computer science company. In his work, the author is focusing on algorithmic problem solving while still remaining interested in applied machine learning.

Table of contents (4 chapters)

Table of contents (4 chapters)

Buy this book

eBook $59.99
price for USA in USD
  • ISBN 978-3-658-12879-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $74.99
price for USA in USD
  • ISBN 978-3-658-12878-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Predicting the Lineage Choice of Hematopoietic Stem Cells
Book Subtitle
A Novel Approach Using Deep Neural Networks
Authors
Series Title
BestMasters
Copyright
2016
Publisher
Springer Spektrum
Copyright Holder
Springer Fachmedien Wiesbaden
eBook ISBN
978-3-658-12879-1
DOI
10.1007/978-3-658-12879-1
Softcover ISBN
978-3-658-12878-4
Series ISSN
2625-3577
Edition Number
1
Number of Pages
XV, 68
Topics