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Atherosclerosis IV

Proceedings of the Fourth International Symposium

Editors: Schettler, G., Goto, Y., Hata, Y., Klose, G. (Eds.)

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About this book

The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero­ sclerotic lesions. We have suggested two alternative explanations for the obser­ vation of monotypism which we believe must be shown to be invalid before accept­ ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive growth of a le­ sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo­ nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.

Table of contents (47 chapters)

  • Arterial Endothelial Permeability to Macromolecules

    Schwartz, C. J. (et al.)

    Pages 1-11

  • The Maintenance of Endothelial Integrity

    Poole, J. C. F.

    Pages 12-15

  • Arterial Smooth Muscle Cells in Atherogenesis: Births, Deaths and Clonal Phenomena

    Thomas, W. A. (et al.)

    Pages 16-23

  • Lipoproteins — Steady State Aspects

    Smith, Elspeth B.

    Pages 24-29

  • Connective Tissue in Atherosclerosis

    Haust, M. Daria

    Pages 30-35

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-642-95308-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-642-95310-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Atherosclerosis IV
Book Subtitle
Proceedings of the Fourth International Symposium
Editors
  • G. Schettler
  • Y. Goto
  • Y. Hata
  • G. Klose
Copyright
1977
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-95308-8
DOI
10.1007/978-3-642-95308-8
Softcover ISBN
978-3-642-95310-1
Edition Number
1
Number of Pages
XLV, 797
Topics