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Nucleic Acids in Immunology

Proceedings of a Symposium Held at the Institute of Microbiology of Rutgers, The State University

Editors: Plescia, O. J., Braun, W. (Eds.)

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About this book

Two fields have played a leading role in biomedical research in recent years, the biochemistry of nucleic acids and immunology. Yet, with the exception of those aspects which have been concerned with antibody synthesis as an example of protein synthesis, there was until recently a lack of direct association between the two fields. Until quite recently the antigenicity of nucleic acids was still in doubt and indeed represented a controversial subject. Also, the exact role of the various nucleic acids in various stages of antibody synthesis was uncertain. These skepticisms and uncertainties disappeared rapidly in the last few years. New experi­ mental approaches brought the realization that nucleic acids, under appropriate conditions, are indeed immunogenic, and that the resulting antibodies can furnish new tools for the exploration of the mplecular structure of the all-important family of nucleic acid molecules. ' At the same time, the recognition of the antigenicity of nucleic acids brought a new level of understanding to certain auto-immune diseases and pro­ vided new material for the exploration of the role of a carrier in immune responses. Side by side with this development was the almost explosive development of new experimental approaches and new ideas pertaining to the problem of antibody formation. Nucleic acids in their various forms were recognized as playing an expected major role in the activation of antibody-forming cells. Perhaps less to be expected was the role they can playas non-specific stimulators of antibody formation.

Table of contents (42 chapters)

  • Reading the Helix Backwards

    Heidelberger, Michael

    Pages 3-4

  • Methylated Bovine Serum Albumin as a Carrier for Oligo- and Poly-Nucleotides

    Plescia, Otto J. (et al.)

    Pages 5-17

  • The Production of Antibodies to Mononucleotides, Oligonucleotides, and DNA

    Parker, C. W. (et al.)

    Pages 18-31

  • Specific Antibodies to Polynucleotide Complexes and their Reaction with Nucleic Acids: Importance of the Secondary Structure of the Antigen

    Lacour, F. (et al.)

    Pages 32-46

  • Specificity in the Reaction between Anti-Pyrimidine Nucleoside Antibodies and DNA

    Garro, A. J. (et al.)

    Pages 47-57

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-87668-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-87670-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Nucleic Acids in Immunology
Book Subtitle
Proceedings of a Symposium Held at the Institute of Microbiology of Rutgers, The State University
Editors
  • O. J. Plescia
  • W. Braun
Copyright
1968
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-3-642-87668-4
DOI
10.1007/978-3-642-87668-4
Softcover ISBN
978-3-642-87670-7
Edition Number
1
Number of Pages
XVII, 724
Topics