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Current Topics in Microbiology and Immunology

Molecular Aspects of Myeloid Stem Cell Development

Editors: Wolff, Linda, Perkins, Archibald S. (Eds.)

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About this book

A workshop on "MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT" was held at the Historic Inns in Annapolis, MD during April 30-May 3, with approximately 70 persons attend­ ing. The enormous success of this meeting was attributable to the recent outburst of information generated from two areas of study: transcriptional regulation of developmentally important myeloid genes and molecular dissection of chromosomal abnormalities in human myeloid leukemias. It was reassuring that studies of normal myelopoiesis and abnormal myelopoiesis, as observed in dys­ plasias and neoplasia, are revealing several interrelated mechan­ isms of gene regulation. However, great challenges await us as we try to determine how these and other mechanisms in this intricate system orchestrate the ultimate fate of cells e. g. proliferation, differentiation or apoptosis. This volume of Current Topics in Micro­ biology encapsulates many of the key aspects of the workshop summarizing research over the past few years on the ontogeny and pathology of myeloid cells. Investigations into the complex process of normal myeloid cell . maturation were first made possible through development of in vitro clonigenic assays. These established the relationships of colony stimulating factors, interleukins and their combinations to the specific fates of myeloid progenitors derived from the bone , marrow and spleen. Molecular studies became feasible, however, through the later establishment of several cell culture systems in­ volving immortalized cells which, under the proper induction, could fairly accurately recapitulate the myelopoietic process.

Table of contents (29 chapters)

Table of contents (29 chapters)
  • Molecular Control of Development in Normal and Leukemic Myeloid Cells by Cytokines, Tumor Suppressor and Oncogenes

    Pages 3-5

    Sachs, L.

  • Retinoic Acid Receptors in Hematopoiesis

    Pages 7-15

    Collins, Steven J. (et al.)

  • Role of c-myc in Myeloid Differentiation, Growth Arrest and Apoptosis

    Pages 17-27

    Hoffman, B. (et al.)

  • Self Renewal and Differentiation in Primary Avian Hematopoietic Cells: An Alternative to Mammalian in Vitro Models?

    Pages 29-39

    Beug, H. (et al.)

  • The Effect of C-raf Antisense Oligonucleotides on Growth Factor-Induced Proliferation of Hematopoietic Cells

    Pages 43-53

    Keller, J. R. (et al.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-85232-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-85234-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Aspects of Myeloid Stem Cell Development
Editors
  • Linda Wolff
  • Archibald S. Perkins
Series Title
Current Topics in Microbiology and Immunology
Series Volume
211
Copyright
1996
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-85232-9
DOI
10.1007/978-3-642-85232-9
Softcover ISBN
978-3-642-85234-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIV, 298
Number of Illustrations
2 illustrations in colour
Topics

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