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Current Topics in Microbiology and Immunology

Transgenic Models of Human Viral and Immunological Disease

Editors: Chisari, Francis V., Oldstone, Michael (Eds.)

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About this book

Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Cytotoxic T Cell Effector and Memory Function in Viral Immunity

    Pages 1-14

    Doherty, P. C.

  • Transgenic Mouse Models of Experimental Autoimmune Encephalomyelitis

    Pages 15-31

    Zaller, D. M. (et al.)

  • The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice

    Pages 33-50

    Flavell, R. A. (et al.)

  • Influence of T Lymphocytes and Major Histocompatibility Complex Class II Genes on Diabetes Susceptibility in the NOD Mouse

    Pages 51-66

    Slattery, R. M. (et al.)

  • Virus-Induced Autoimmune Disease: Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis

    Pages 67-83

    Oldstone, M. B. A. (et al.)

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-3-642-85208-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-642-85210-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Transgenic Models of Human Viral and Immunological Disease
Editors
  • Francis V. Chisari
  • Michael Oldstone
Series Title
Current Topics in Microbiology and Immunology
Series Volume
206
Copyright
1996
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-85208-4
DOI
10.1007/978-3-642-85208-4
Softcover ISBN
978-3-642-85210-7
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XI, 348
Topics

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