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Recent Results in Cancer Research

Recent Advances in Cell Biology of Acute Leukemia

Impact on Clinical Diagnosis and Therapy

Editors: Ludwig, Wolf-Dieter, Thiel, Eckhard (Eds.)

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  • ISBN 978-3-642-84895-7
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Softcover $159.00
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About this book

The development of new techniques such as immuno­ phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono­ clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho­ genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo­ somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop­ ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell­ biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con­ tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.

Table of contents (35 chapters)

Table of contents (35 chapters)
  • Differentiation of Physiological and Malignant Cells of the B-Cell System

    Pages 1-7

    Stein, H.

  • Expression of B-Cell-Associated Antigens During B-Cell Ontogeny

    Pages 9-18

    Dörken, B.

  • Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia

    Pages 19-30

    Campana, D. (et al.)

  • Flow Cytometric Analysis of Intracellular Myeloperoxidase and Lactoferrin in Leukemia Diagnosis

    Pages 31-40

    Knapp, W. (et al.)

  • Immunological, Ultrastructural and Molecular Features of Unclassifiable Acute Leukaemia

    Pages 41-52

    Matutes, E. (et al.)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-84895-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-84897-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Recent Advances in Cell Biology of Acute Leukemia
Book Subtitle
Impact on Clinical Diagnosis and Therapy
Editors
  • Wolf-Dieter Ludwig
  • Eckhard Thiel
Series Title
Recent Results in Cancer Research
Series Volume
131
Copyright
1993
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-84895-7
DOI
10.1007/978-3-642-84895-7
Softcover ISBN
978-3-642-84897-1
Series ISSN
0080-0015
Edition Number
1
Number of Pages
XV, 407
Number of Illustrations
3 illustrations in colour
Topics