Recent Advances in Cell Biology of Acute Leukemia
Impact on Clinical Diagnosis and Therapy
Editors: Ludwig, Wolf-Dieter, Thiel, Eckhard (Eds.)
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- About this book
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The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.
- Table of contents (35 chapters)
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Differentiation of Physiological and Malignant Cells of the B-Cell System
Pages 1-7
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Expression of B-Cell-Associated Antigens During B-Cell Ontogeny
Pages 9-18
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Normal and Aberrant T-Cell Receptor Protein Expression in T-Cell Acute Lymphoblastic Leukemia
Pages 19-30
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Flow Cytometric Analysis of Intracellular Myeloperoxidase and Lactoferrin in Leukemia Diagnosis
Pages 31-40
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Immunological, Ultrastructural and Molecular Features of Unclassifiable Acute Leukaemia
Pages 41-52
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Table of contents (35 chapters)
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Bibliographic Information
- Bibliographic Information
-
- Book Title
- Recent Advances in Cell Biology of Acute Leukemia
- Book Subtitle
- Impact on Clinical Diagnosis and Therapy
- Editors
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- Wolf-Dieter Ludwig
- Eckhard Thiel
- Series Title
- Recent Results in Cancer Research
- Series Volume
- 131
- Copyright
- 1993
- Publisher
- Springer-Verlag Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- eBook ISBN
- 978-3-642-84895-7
- DOI
- 10.1007/978-3-642-84895-7
- Softcover ISBN
- 978-3-642-84897-1
- Series ISSN
- 0080-0015
- Edition Number
- 1
- Number of Pages
- XV, 407
- Number of Illustrations
- 3 illustrations in colour
- Topics
