HLA in Narcolepsy

1. Front Matter

   Pages I-XII

   PDF

2. Introduction

   • Y. Honda

   Pages 1-9

3. An Overview of the HLA System

   • T. Juji

   Pages 10-23

4. Clinical Features of Narcolepsy: Japanese Experiences

   • Y. Honda

   Pages 24-57

5. HLA in Narcolepsy in Japan

   • K. Matsuki, Y. Honda, M. Satake, T. Juji

   Pages 58-75

6. HLA in Narcolepsy/Cataplexy in the United Kingdom

   • C. B. Lock, K. I. Welsh, J. D. Parkes, A. So, D. C. Briggs, R. W. Vaughan et al.

   Pages 76-88

7. HLA in Narcolepsy in France

   • M. Billiard, J. Seignalet, H. Betuel, A. Marcadet, L. Gebuhrel, A. C. Freidel et al.

   Pages 89-96

8. HLA in Narcolepsy in Canada

   • J. Montplaisir, G. Poirier

   Pages 97-107

9. HLA-DR2 and the Narcolepsy Syndrome: The Stanford Experience

   • C. Guilleminault, J. Holloman, C. Grumet, T. Kilduff, H. O. McDevitt, W. C. Dement et al.

   Pages 108-113

10. Narcolepsy and HLA in the Federal Republic of Germany: Population and Family Data

    • K. Meier-Ewert, G. Mueller-Eckhardt, D. J. Schendel

    Pages 114-120

11. Positive HLA-Dw2 in Narcolepsy

    • T. Naohara, Y. Honda, T. Juji

    Pages 121-129

12. HLA-Linked Complement Markers in Narcolepsy

    • K. Tokunaga, K. Matsuki, T. Juji, Y. Honda

    Pages 130-136

13. DNA Typing in Narcolepsy

    • H. Inoko

    Pages 137-149

14. Immunological Features of Narcolepsy in Japan

    • K. Matsuki, T. Juji, Y. Honda

    Pages 150-157

15. Immune Factors in Narcolepsy in the United Kingdom

    • J. D. Parkes, K. Welsh, N. Langdon, C. Lock

    Pages 158-171

16. Disorders of Excessive Daytime Sleepiness Without Cataplexy, and Their Relationship with HLA in Japan

    • S. Harada, K. Matsuki, Y. Honda, T. Someya

    Pages 172-185

17. HLA in Disorders of Excessive Daytime Sleepiness Without Cataplexy in Canada

    • J. Montplaisir, G. Poirier

    Pages 186-190

18. Genetic Markers Other than HLA in Narcolepsy

    • A. Asaka, K. Matsuki, M. Uchikawa, T. Juji, Y. Honda

    Pages 191-201

19. Back Matter

    Pages 203-208

    PDF

The Second International Symposium on Narcolepsy was held at Fairchild Auditorium, Stanford University, on 6-7 July 1985 under the presidency of Drs. William C. Dement and Christian Guillemi­ nault. It succeeded the First International Symposium on Narco­ lepsy held in La Grande Motte, France, organized by Pierre Pas­ souant in July 1975 in commemoration of the 100th anniversary of the publication of Jean B. E. Gelineau's paper which proposed the naming of narcolepsy. At the second narcolepsy symposium, many important research reports on both basic and clinical aspects of narcolepsy were given by investigators from many countries of the world. Audience inter­ est was particularly attracted by the section on the relationship be­ tween HLA and narcolepsy, in which recent evidence that almost all narcoleptic patients are HLA-DR2 positive was reported by in­ vestigators from Japan, England, France, Canada, and the United States. The close relationship between the HLA antigens, hitherto considered as immune-related genetic markers encoded by genes on human chromosome 6, and narcolepsy appeared to open a new approach not only for the research of narcolepsy but also for the mechanism of sleep in general. Publication of all these new findings on the association of HLA and narcolepsy was considered; an outline was worked out and all the groups agreed to prepare a contribution covering the various aspects of this topic.

• Antigen
• DNA
• Syndrom
• blood
• diagnosis
• syndromes

• Neuropsychiatric Research Institute, Seiwa Hospital, Shinjuku-ku, Tokyo, Japan

  Yutaka Honda

• Blood Transfusion Service, Tokyo University Hospital, Bunkyo-ku, Tokyo, Japan

  Takeo Juji

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