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Recent Results in Cancer Research

Adjuvant Therapies of Cancer

Editors: Mathe;&AAe;, Georges, Bonadonna, G., Salmon, S. (Eds.)

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About this book

Transplantation of syngeneic (donor is a monozygous twin) or allogeneic (donor is an HLA-identical sibling) marrow provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity. Until 1975, marrow transplantation was carried out only after failure of all other therapy. Consequently, most patients were in advanced relapse. Six of 16 recipients of syngeneic marrow and 13 of 100 recipients of allogeneic marrow are still in remission after 5. 5-10 years [3, 7]. An actuarial survival curve of the first 100 patients grafted in Seattle after conditioning with cyclophos­ phamide (60 mg/kg on each of 2 successive days) and total body irradiation (1,000 rad) showed three periods of interest: (1) The first 4 months showed a rapid loss of patients associated with advanced illness, graft-versus-host disease, infections (in particular interstitial pneumonias), and recurrent leukemia; (2) from 4 months to 2 years, the curve showed a much slower rate of decline attributable primarily to recurrent leukemia; and (3) from 2-10 years, the curve was almost flat with a negligible loss of patients and no recurrent leukemia. This flat portion of the curve corresponded to 13% of the patients and indicates a strong probability that the majority of these survivors are cured of their disease [8]. Attempts at reducing the incidence of leukemic relapse after transplantation were made by a number of marrow transplant groups by added chemotherapy.

Table of contents (57 chapters)

Table of contents (57 chapters)
  • Metastatic Potential of Metastases, Tumor Cell Heterogeneity, and Therapeutic Implications

    Pages 1-8

    Spreafico, F. (et al.)

  • Immune Imbalance and Immune Modulation in Solid Tumor Patients: New Insights

    Pages 9-16

    Serrou, B. (et al.)

  • Markers of Minimal Residual Disease

    Pages 17-21

    Neville, A. M.

  • Radiotherapy as Adjuvant Local Therapy of Local Tumors

    Pages 22-25

    Chassagne, D.

  • Comparison of HLA Phenotypes in Long-Term Survivors with Acute Lymphoblastic Leukemia Treated with Immunotherapy Versus Chemotherapy

    Pages 26-28

    Tursz, T. (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-81685-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-81687-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Adjuvant Therapies of Cancer
Editors
  • Georges Mathe;&AAe;
  • G. Bonadonna
  • S. Salmon
Series Title
Recent Results in Cancer Research
Series Volume
80
Copyright
1982
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-81685-7
DOI
10.1007/978-3-642-81685-7
Softcover ISBN
978-3-642-81687-1
Series ISSN
0080-0015
Edition Number
1
Number of Pages
XVI, 358
Topics