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Recent Results in Cancer Research

Chemotherapy and Radiotherapy of Gastrointestinal Tumors

Editors: Klein, H.O. (Ed.)

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About this book

Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in the advanced disease [10]. Of the few drugs which are active in the advanced disease, only 5-fluorouracil (5-FU) and razoxane «±1,2-bis(3,4-dioxopiperazin-1-yl)propane) are suitable for long-term adjuvant treatment [2, 9]. 5-FU has been widely and intensively studied as adjuvant chemotherapy in CRC [7], but there is no unanimity that it has even the marginal influence on survival that has been claimed [3, 10]. Razoxane has not previously been tested for adjuvant or maintenance treatment in CRC. It has however a number of biological activities which might be thought useful in the treatment of residual or minimal tumours [1] and which might therefore make it useful as an adjuvant. Thus it specifically prevents tumour dissemination and metastases in some tumours and normalizes the neovasculature which the tumours induce [6, 8, 11]. The drug is not cytotoxic in the usual sense, does not affect non-dividing cells, and only blocks cell division during a brief period of the cell cycle in late G and/or early mitosis [12]. It does so non-selectively and most cells capable of 2 division examined so far have been affected by the drug. Even affected cells however are not destroyed immediately, but may increase in size and become multinucleate [5].

Table of contents (11 chapters)

Table of contents (11 chapters)
  • The Importance of Lectin Binding Sites and Carcinoembryonic Antigen with Regard to Normal, Hyperplastic, Adenomatous, and Carcinomatous Colonic Mucosa

    Pages 1-9

    Klein, P. J. (et al.)

  • Why Do Colon Tumours Respond Poorly to Chemotherapeutic Agents?

    Pages 10-18

    Putten, L. M. (et al.)

  • Prospective and Controlled Studies on Multidisciplinary Treatment in Gastrointestinal Cancer

    Pages 19-27

    Gérard, A. (et al.)

  • Recent Results of Clinical Therapeutic Trials for Gastrointestinal Malignancies Conducted in the United States

    Pages 28-40

    Kisner, D. L. (et al.)

  • Effectiveness of Postoperative Adjuvant Therapy with Cytotoxic Chemotherapy (Cytosine Arabinoside, Mitomycin C, 5-Fluorouracil) or Immunotherapy (Neuraminidase-Modified Allogeneic Cells) in the Prevention of Recurrence of Duke’s B and C Colon Cancer

    Pages 41-47

    Rainer, H. (et al.)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-3-642-81681-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-81683-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chemotherapy and Radiotherapy of Gastrointestinal Tumors
Editors
  • H.O. Klein
Series Title
Recent Results in Cancer Research
Series Volume
79
Copyright
1981
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-81681-9
DOI
10.1007/978-3-642-81681-9
Softcover ISBN
978-3-642-81683-3
Series ISSN
0080-0015
Edition Number
1
Number of Pages
VI, 112
Number of Illustrations
7 b/w illustrations
Topics

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