Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik

Chemical Recognition in Biology

Editors: Chapeville, F., Haenni, A. L. (Eds.)

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About this book

Studies of chemical recognition in biology were initiated about half a century ago with the flrst kinetic data obtained on enzyme catalysis and inhibition. They led to a rather static representation of the recognition process illustrated by the lock and key model that still continues to influence our overall image of recognition and its specificity. In several cases, crystallographic studies of enzyme-substrate complexes have supported this model. Indeed, in a crystallized ligand-enzyme complex, a close fltting is observed between the active center of the enzyme and the functional groups of the ligand. How­ ever, this does not necessarily result from a direct recognition process between rigid structures, but may result from a progressive adaptation during which the initial struc­ tures of the enzyme and the ligand are modified (induced-flt mechanism). Recently, a great deal of work has been devoted to the study of recognition in more complex systems such as the replication or the translation machin~ries; clearly, the extraordinary precision of such systems cannot be explained solely in terms of physical matching between enzymes and their substrates. This has led to a noticeable change of perspective in these areas. As a result of the new kinetic viewpoint, one rather focuses on the time-course of the processes, on the kinetic balance between steps of the reaction, on the energy-accuracy relationships and on the strategies which permit the achievement of high precision using relatively error-prone components in an appropriate dynamic interplay.

Table of contents (31 chapters)

Table of contents (31 chapters)
  • What Everyone Wanted to Know About Tight Binding and Enzyme Catalysis, but Never Thought of Asking

    Pages 3-25

    Jencks, W. P.

  • The Cytochromes C: Paradigms for Chemical Recognition

    Pages 26-37

    Kamen, M. D.

  • Recognition of Ligands by Haem Proteins

    Pages 38-42

    Perutz, M. F.

  • Influences of Solvent Water on the Transition State Affinity of Enzymes, Protein Folding, and the Composition of the Genetic Code

    Pages 43-61

    Wolfenden, R.

  • Suicide Substrates: Mechanism-Based Inactivators of Specific Target Enzymes

    Pages 62-77

    Walsh, C.

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-81503-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-81505-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Chemical Recognition in Biology
Editors
  • F. Chapeville
  • A. L. Haenni
Series Title
Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik
Series Volume
32
Copyright
1980
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin · Heidelberg
eBook ISBN
978-3-642-81503-4
DOI
10.1007/978-3-642-81503-4
Softcover ISBN
978-3-642-81505-8
Series ISSN
0077-0221
Edition Number
1
Number of Pages
IX, 430
Topics