Selective Heat Sensitivity of Cancer Cells

1. Front Matter

   Pages I-XII

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2. Introduction

   • B. C. Giovanella, B. Mondovi

   Pages 1-6

3. Biochemical Aspects of Heat Sensitivity of Tumour Cells

   • R. Strom, C. Crifo, A. Rossi-Fanelli, B. Mondovi

   Pages 7-35

4. Actions of Hyperthermia on Tumor Cells Cultured in vitro

   • B. C. Giovanella

   Pages 36-42

5. The Effects of Hyperthermia in Animal Tumour Systems

   • J. A. Dickson

   Pages 43-111

6. Addendum

   • Alessandro Rossi-Fanelli, Renato Cavaliere, Bruno Mondovì, Guido Moricca

   Pages 111-111

7. Hyperthermic Treatment of Tumours: Experimental and Clinical Applications

   • G. Moricca, R. Cavaliere, A. Caputo, A. Bigotti, F. Colistro

   Pages 112-152

8. Whole-Body Hyperthermia. A Systemic Treatment for Disseminated Cancer

   • R. T. Pettigrew, C. M. Lugate

   Pages 153-170

9. Hyperthermic Perfusion of Extremities for Melanoma and soft Tissue Sarcomas

   • J. S. Stehlin Jr., B. C. Giovanella, P. D. de Ipolyi, L. R. Muenz, R. F. Anderson, A. A. Gutierrez

   Pages 171-185

10. Back Matter

    Pages 187-192

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Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio­ chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

• Heat
• Sensitivity
• cancer
• cell
• tumors

• Institute of Biological Chemistry, University of Rome, Rome, Italy

  Alessandro Rossi-Fanelli

• Center of Molecular Biology, C.N.R., Rome, Italy

  Alessandro Rossi-Fanelli

• Regina Elena Institute for Cancer Research, Rome, Italy

  Renato Cavaliere, Guido Moricca

• Institute of Applied Biochemistry, University of Rome, Rome, Italy

  Bruno Mondovì

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