Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik

Hemoglobin

Cooperativity and Electronic Properties

Authors: Weissbluth, M.

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Approximately one third of the mass of a mammalian red blood cell is hemo­ globin. Its major function is to bind oxygen at the partial pressure prevailing in the lungs and to release it to the tissues where the partial pressure is lower. The process whereby hemoglobin performs this essential physiological role is characterized by a cooperative interaction among its constituent subunits. A great deal of research effort has been devoted to this interaction, going back at least as far as the fitst decade of this century. Moreover, cooperativity in hemo­ globin is probably not unique; it may well be one instance of a general class of interactions that occur in biological molecules. Certain enzymes with a variety of regulatory and catalytic functions, for example, contain several sites which interact in a highly specific manner such that the affinity of a given site for the substrate is markedly influenced by the state of binding at the other sites. But whereas we know very little of the structure of most enzymes of this type, hemo­ globin is one of a very small number of biological molecules whose immensely intricate machinery has been revealed to us. We owe this insight to the group under the leadership of M. F. PERUTZ in Cambridge, England, whose research over a period of several decades culminated in a detailed description of the three­ dimensional structure.

Table of contents (9 chapters)

Table of contents (9 chapters)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-80801-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-80803-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hemoglobin
Book Subtitle
Cooperativity and Electronic Properties
Authors
Series Title
Molecular Biology, Biochemistry and Biophysics Molekularbiologie, Biochemie und Biophysik
Series Volume
15
Copyright
1974
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-80801-2
DOI
10.1007/978-3-642-80801-2
Softcover ISBN
978-3-642-80803-6
Series ISSN
0077-0221
Edition Number
1
Number of Pages
VIII, 176
Number of Illustrations
1 b/w illustrations
Topics