Overview
- Editors:
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Hilary Koprowski
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Department of Microbiology and Immunology Center for Neurobiology, Thomas Jefferson University, Philadelphia, USA
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David B. Weiner
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Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, Philadelphia, USA
- Enables the reader to understand how to apply important emerging technology to a new generation of vaccines and therapies
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Table of contents (11 chapters)
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Front Matter
Pages I-XVII
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- P. A. Benton, R. C. Kennedy
Pages 1-20
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- B. Wang, A. P. Godillot, M. P. Madaio, D. B. Weiner, W. V. Williams
Pages 21-35
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- D. L. Doolan, R. C. Hedstrom, M. J. Gardner, M. Sedegah, H. Wang, R. A. Gramzinski et al.
Pages 37-56
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- B. T. Rouse, S. Nair, R. J. D. Rouse, Z. Yu, N. Kuklin, K. Karem et al.
Pages 69-78
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- C. J. Pachuk, R. Arnold, K. Herold, R. B. Ciccarelli, T. J. Higgins
Pages 79-89
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- L. A. Babiuk, P. J. Lewis, S. Drunen Little-Van van den Hurk, S. Tikoo, X. Liang
Pages 90-106
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- M. L. Bagarazzi, J. D. Boyer, V. Ayyavoo, D. B. Weiner
Pages 107-143
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- J. F. Warner, D. J. Jolly, J. Merritt
Pages 145-160
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- M. G. Agadjanyan, B. Wang, S. B. Nyland, D. B. Weiner, K. E. Ugen
Pages 175-192
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Back Matter
Pages 193-201
About this book
Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.
Editors and Affiliations
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Department of Microbiology and Immunology Center for Neurobiology, Thomas Jefferson University, Philadelphia, USA
Hilary Koprowski
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Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, Philadelphia, USA
David B. Weiner