Current Topics in Microbiology and Immunology

Pathology of Septic Shock

Editors: Rietschel, Ernst T., Wagner, Hermann (Eds.)

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About this book

Severe sepsis and septic shock are the most serious compli­ cations of bacterial infections. Both gram-positive and gram­ negative bacteria can trigger these extreme inflammatory re­ sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem­ istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan­ isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.

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Table of contents (14 chapters)

Table of contents (14 chapters)
  • Definition and Pathogenesis of Septic Shock

    Pages 1-13

    Vincent, J. L.

  • Significance and Pathogenesis of Septic Shock

    Pages 15-37

    Brandtzaeg, P.

  • Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification

    Pages 39-81

    Rietschel, E. T. (et al.)

  • Superantigen-Mediated Lethal Shock: The Functional State of Ligand-Reactive T Cells

    Pages 83-100

    Heeg, K. (et al.)

  • Pathogenesis of Sepsis Syndrome: Possible Relevance of Pore-Forming Bacterial Toxins

    Pages 101-118

    Bhakdi, S. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-642-80186-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-80188-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Pathology of Septic Shock
Editors
  • Ernst T. Rietschel
  • Hermann Wagner
Series Title
Current Topics in Microbiology and Immunology
Series Volume
216
Copyright
1996
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-80186-0
DOI
10.1007/978-3-642-80186-0
Softcover ISBN
978-3-642-80188-4
Series ISSN
0070-217X
Edition Number
1
Number of Pages
X, 321
Topics