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The CD4 Molecule

Roles in T Lymphocytes and in HIV Disease

  • Book
  • © 1996

Overview

Editors:
  1. Dan R. Littman

    1. Howard Hughes Medical Institute, Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 205)

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Table of contents (8 chapters)

  1. Front Matter

    Pages I-XIII
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  2. The Structure of CD4

    • R. L. Brady, A. N. Barclay
    Pages 1-18

  3. The Structural Basis of CD4 — MHC Class II Interactions: Coreceptor Contributions to T Cell Receptor Antigen Recognition and Oligomerization-Dependent Signal Transduction

    • R. König, S. Fleury, R. N. Germain
    Pages 19-46

  4. CD4 and Signal Transduction

    • K. S. Ravichandran, T. L. Collins, S. J. Burakoff
    Pages 47-62

  5. Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck

    • R. Weil, A. Veillette
    Pages 63-87

  6. The Regulation and Function of the CD4 Coreceptor During T Lymphocyte Development

    • N. Killeen, D. R. Littman
    Pages 89-106

  7. Endocytic and Exocytic Regulation of CD4 Expression and Function

    • M. Marsh, A. Pelchen-Matthews
    Pages 107-135

  8. The Receptor for HIV: Dissection of CD4 and Studies on Putative Accessory Factors

    • W. James, R. A. Weiss, J. H. M. Simon
    Pages 137-158

  9. The Role of CD4 in HIV Envelope-Mediated Pathogenesis

    • R. F. Siliciano
    Pages 159-179

  10. Back Matter

    Pages 181-184
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Keywords

About this book

During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug­ gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.

Reviews

"...will undoubtedly provide an outstanding reference for students and researchers for some years to come." - Immunology Today

Editors and Affiliations

  • Howard Hughes Medical Institute, Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, USA

    Dan R. Littman

Bibliographic Information

  • Book Title: The CD4 Molecule

  • Book Subtitle: Roles in T Lymphocytes and in HIV Disease

  • Editors: Dan R. Littman

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-79798-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1996

  • Softcover ISBN: 978-3-642-79800-9Published: 30 December 2011

  • eBook ISBN: 978-3-642-79798-9Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIII, 182

  • Number of Illustrations: 1 illustrations in colour

  • Topics: Immunology, Virology

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