Current Topics in Microbiology and Immunology

The CD4 Molecule

Roles in T Lymphocytes and in HIV Disease

Editors: Littman, Dan R. (Ed.)

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About this book

During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug­ gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.

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"...will undoubtedly provide an outstanding reference for students and researchers for some years to come." - Immunology Today

Table of contents (8 chapters)

Table of contents (8 chapters)
  • The Structure of CD4

    Brady, R. L. (et al.)

    Pages 1-18

  • The Structural Basis of CD4 — MHC Class II Interactions: Coreceptor Contributions to T Cell Receptor Antigen Recognition and Oligomerization-Dependent Signal Transduction

    König, R. (et al.)

    Pages 19-46

  • CD4 and Signal Transduction

    Ravichandran, K. S. (et al.)

    Pages 47-62

  • Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck

    Weil, R. (et al.)

    Pages 63-87

  • The Regulation and Function of the CD4 Coreceptor During T Lymphocyte Development

    Killeen, N. (et al.)

    Pages 89-106

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-79798-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-79800-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The CD4 Molecule
Book Subtitle
Roles in T Lymphocytes and in HIV Disease
Editors
  • Dan R. Littman
Series Title
Current Topics in Microbiology and Immunology
Series Volume
205
Copyright
1996
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-79798-9
DOI
10.1007/978-3-642-79798-9
Softcover ISBN
978-3-642-79800-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XIII, 182
Number of Illustrations
1 illustrations in colour
Topics