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Current Topics in Microbiology and Immunology

Pathways for Cytolysis

Editors: Griffiths, Gillian M., Tschopp, Jürg (Eds.)

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About this book

At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring or generated by gene targeting. It is now clear that there are two predominant pathways which act hand in hand and lead to efficienttarget cell destruction.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Perforin and Granzymes: Crucial Effector Molecules in Cytolytic T Lymphocyte and Natural Killer Cell-Mediated Cytotoxicity

    Pages 1-24

    Lowin, B. (et al.)

  • Fas-Based T Cell-Mediated Cytotoxicity

    Pages 25-37

    Golstein, P.

  • Structure and Biogenesis of Lytic Granules

    Pages 39-58

    Griffiths, G. M. (et al.)

  • The Role of CD28 Costimulation in the Generation of Cytotoxic T Lymphocytes

    Pages 59-74

    Azuma, M. (et al.)

  • Degranulating Cytotoxic Lymphocytes Inflict Multiple Damage Pathways on Target Cells

    Pages 75-93

    Henkart, P. A. (et al.)

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-79414-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-79416-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pathways for Cytolysis
Editors
  • Gillian M. Griffiths
  • Jürg Tschopp
Series Title
Current Topics in Microbiology and Immunology
Series Volume
198
Copyright
1995
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-79414-8
DOI
10.1007/978-3-642-79414-8
Softcover ISBN
978-3-642-79416-2
Series ISSN
0070-217X
Edition Number
1
Number of Pages
IX, 224
Number of Illustrations
3 illustrations in colour
Topics

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