Autoimmunity: Experimental Aspects

1. Front Matter

   Pages I-XVI

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2. Thymic Selection and Peripheral T cell Tolerance

   1. Tolerance induction in mature peripheral T cells

      • Bernd Arnold, Günther Schönrich, Iris Ferber, Judith Alferink, Günter J. Hämmerling

      Pages 1-9

   2. Transgenic mice carrying the rearranged T cell receptor of a diabetogenic T cell clone

      • Jonathan D. Katz, Bo Wang, Christophe Benoist, Diane Mathis

      Pages 11-28

   3. The maintenance and reestablishment of self-tolerance: T cell receptor (TCR) peptide-specific regulatory T cells

      • Vipin Kumar, Eli Sergarz

      Pages 29-37

   4. Prevention of gastric autoimmunity by transgenic expression of a proton pump subunit in the thymus

      • Ban-Hock Toh, Frank Alderuccio, Seong-Seng Tan, Paul A. Gleeson, Ian R. Van Driel

      Pages 39-44

3. B-cell repertoire selection

   1. The Anti-Self B Cell Repertoire

      • Robert S. Schwartz

      Pages 45-50

   2. In vivo suppression of IgG2ab production accomplished by CD4+8− Th1 cell clones specific for a γ2ab allopeptide determinant

      • Kristian Bartnes, Kristian Hannestad

      Pages 51-57

4. Targets of the autoimmune response

   1. Expression cloning using antibodies from a patient with rheumatoid arthritis of an autoantigen homologous to the Drosophila splicing regulator, suppressor-of-white-apricot

      • Robert Lafyatis, André Capron

      Pages 59-73

   2. Use of synthetic peptides for the analysis of B-cell epitopes in autoantigens

      • Sylviane Muller

      Pages 75-90

   3. Molecular mimicry as a mechanism of induction of autoantibodies

      • Paola Migliorini, Barbara Marchini, Maria Pia Dolcher, Alessandra Sabbatini, Antonio Puccetti

      Pages 91-97

   4. The Expression of Heat Shock Proteins in Systemic Lupus Erythematosus

      • Veena B. Dhillon, David S. Latchman, David A. Isenberg

      Pages 99-129

5. Trigger Mechanisms of autoantibody production

   1. The heavy chain variable region genes of human lupus autoantibodies

      • Christophe Demaison, Patricia Chastagner, Céline Bensimon, Moncef Zouali

      Pages 131-149

   2. Molecular analysis of anti-dsDNA autoantibodies from patients with systemic lupus erythematosus

      • Holger K. Fehr, Thomas H. Winkler, Joachim R. Kalden

      Pages 151-161

   3. Differential usage of an autoantibody-associated VH gene by human B-cell tumors

      • Freda K. Stevenson, Myfanwy B. Spellerberg, Joanna Treasure, Caroline J. Chapman, Leslie E. Silberstein, Terry J. Hamblin et al.

      Pages 163-172

   4. Idiotypes of DNA-Binding Autoantibodies:Mapping by Epitope Scanning and Molecular Modelling

      • Norman A. Staines, Francis J. Ward, Paul Hobby, Andrew N. Denbury, Sukhvinder Bansal, Brian J. Sutton et al.

      Pages 173-189

6. T Cell Receptor Genes

   1. T cell receptor variable gene repertoire in rheumatoid synovial T cells responding to BCG

      • Jacob B. Natvig, Kay B. Wilson, Alison Quayle, Sel Suleyman, Jens Kjeldsen-Kragh, Øystein Førre et al.

      Pages 191-196

   2. An Analysis of T cell receptor diversity in the NOD mouse: What can it tell us about the autoimmune process?

      • Adelaida Sarukhan, Henri-Jean Garchon, Claude Carnaud

      Pages 197-212

   3. Possible Linkage of Myasthenia Gravis Susceptibility in R111 S/J Mice to a Genomic Deletion of T Cell Receptor Vβ Genes

      • Mohan Shenoy, Bo Wu, Rashmi Kaul, Elzbieta Goluszko, Chella David, Premkumar Christadoss

      Pages 213-220

   4. Genetic and environmental factors in Systemic lupus erythematosus

      • Pierre Youinou, Gilbert Semana, Jean-Charles Piette, Sylviane Muller, Jatinderpal Kalsi, David A. Isenberg et al.

      Pages 221-227

7. Animal Models and Immunointervention

   1. Role of Immunocompetent Cells in Skin Sclerosis and Autoimmunity in Tight Skin Mice

      • Constantin Bona, Shinobu Shibata, Christian Daian, Kuppuswamy Kasturi

      Pages 229-243

Combining principles of contemporary immunology with applications to immunopathology, this up-to-date volume documents new developments in the understanding of the origin of autoimmune diseases. Emphasized are cellular and molecular approaches in both organ-specific and systemic autoimmunity. A comprehensive bibliography, numerous illustrations, and tables make it an invaluable source of information for immunologists, rheumatologists, pathologists, dermatologists, and nephrologists.

• Autoimmunkrankheit
• Immunity
• Immunologie
• Immunology
• Immunopathology
• Immunpathologie
• autoimmune disease

• Institut Pasteur, Paris, France

  Moncef Zouali

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