Cellular Mechanisms of Sensory Processing

1. Front Matter

   Pages I-XI

   PDF

2. Characterization of the Primary Afferent

   1. Front Matter

      Pages 1-1

      PDF

   2. Diversity of Somatic Spikes in Dorsal Root Ganglion Cells: Implications for Development, Function and Plasticity

      • Lorne M. Mendell

      Pages 3-18

   3. Ion Channels Underlying Transduction and Adaptation in Mechanoreceptors

      • Andrew S. French

      Pages 19-34

   4. Signal Transduction Processes in Sensorimotor Neurons of the Enteric Nervous System

      • Annmarie Surprenant

      Pages 35-45

   5. Modulation of Voltage Dependent Calcium Channels by GABAb Receptors and G Proteins in Cultured Rat Dorsal Root Ganglion Neurons: Relevance to Transmitter Release and Its Modulation

      • Annette C. Dolphin, Anatole Menon-Johansson, Veronica Campbell, Nick Berrow, Marva I. Sweeney

      Pages 47-61

   6. Signal Integration in the Axon Tree due to Branch Point Filtering Action

      • S. David Stoney Jr.

      Pages 63-85

   7. Polymodality in Nociceptive Neurons: Experimental Models of Chemotransduction

      • Carlos Belmonte, Juana Gallar, Laura G. Lopez-Briones, Miguel A. Pozo

      Pages 87-117

   8. Chemical Excitation and Sensitization of Nociceptors

      • Peter W. Reeh

      Pages 119-131

   9. Local Effector Functions of Primary Afferent Nerve Fibres

      • Peter Holzer

      Pages 133-147

3. Transmitters in the Somatosensory System (Synaptology of the Spinal Cord)

   1. Front Matter

      Pages 149-149

      PDF

   2. Exitatory Amino Acid Receptors in the In Vitro Mammalian Spinal Cord

      • Aharon Lev-Tov, M. Pinco

      Pages 151-160

   3. Modulation of NMDA Currents in Hippocampal Neurones

      • Pìotr Bregestovski, Igor Medina, Yezekiel Ben-Ari

      Pages 161-172

   4. Excitatory Amino Acid Receptors in the Spinal Cord

      • David Lodge, Ann Bond

      Pages 173-183

   5. Excitatory Amino Acid Release in Dorsal Root Ganglion Cultures

      • Fang Liu, Ksenija Jeftinija, Srdija Jeftinija

      Pages 185-193

   6. The Involvement of Excitatory Amino Acids and their Receptors in the Spinal Processing of Nociceptive Input from the Normal and Inflamed Knee Joint in the Rat

      • Hans-Georg Schaible, Volker Neugebauer, Thomas Lücke

      Pages 195-215

   7. Tachykinin Receptors and their Antagonists

      • Carlo Alberto Maggi, Alessandro Lecci

      Pages 217-230

   8. Synaptic Activation by the Release of Peptides

      • J. L. Henry, V. Radhakrishnan

      Pages 231-254

   9. TRH and Substance P Increase Rat Motoneurone Excitability through a Block of a Novel K+ Conductance

      • A. Nistri, N. D. Fisher, G. Baranauskas

      Pages 255-269

4. Dynamic Changes in the Sensory System

   1. Front Matter

      Pages 271-271

      PDF

The research field of somatosensory processing in mammals has experienced revolutionary changes in recent years. Accumulation of basic and clinical data has greatly accelerated, and new phenomena have emerged. With the aid of new, refined methods, molecular and cellular changes have been described, underlying the signal transduction-transmission between the internal/external environment and the central nervous system have been described. The discovery of the interaction between the nervous and the immune system has, for example changed our view on the development of inflammatory diseases, while the cloning of genes encoding different trophic factors has boosted studies revealing profound changes in the regeneration of neurons, and induction of changes in phenotype. The study of the pre-and postsynaptic modulation of transmitter release, and the examination of the combined effects of amino acid and peptide transmitters has become recently possible by using cultured cell lines and in vitro techniques. Although it is in embryonic state, computational properties of single DRG cells under normal and pathological conditions are being investigated. Results soon or later will have a great impact on pain research and consequently ultimately in clinical pain management. This brief introduction indicates how our knowledge of the somatosensory system has increased dramatically recently. However, many investigators cultivate only a very specific field in the growing area of somatosensory research and find it difficult to integrate a more universal knowledge of their work.

• Immune System
• Nervous System
• Neurochemie
• Neuronen
• Reizleitung
• Sensory Processing
• Sinnesphysiologie
• cellular mechanisms
• neurochemistry
• neurones
• sensorimotor neurones

• Sandoz Institute for Medical Research, London, UK

  Laszlo Urban

Policies and ethics