Overview
- Editors:
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Peter G. Welling
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Pharmacokinetics/Drug Metabolism Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, USA
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Luc P. Balant
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Clinical Research Unit, Department of Psychiatry, Geneva, Switzerland
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Table of contents (18 chapters)
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Front Matter
Pages I-XXVI
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Analytical Methods
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- G. D. Nordblom, C. M. Barksdale
Pages 23-39
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- B. L. Ferraiolo, M. A. Mohler
Pages 85-98
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In Vitro Methods-Protein and Tissue Binding
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- J. P. F. Bai, B. H. Stewart, G. L. Amidon
Pages 189-206
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Classical Problems
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Front Matter
Pages 207-207
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- L. P. Balant, P. G. Welling
Pages 233-263
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- H. K. Kroemer, G. Mikus, M. Eichelbaum
Pages 265-288
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- O. Pelkonen, D. D. Breimer
Pages 289-332
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- N. H. G. Holford, T. M. Ludden
Pages 333-352
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Future Trends in Pharmacokinetics
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Front Matter
Pages 353-353
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- B. L. Ferraiolo, R. J. Wills, M. A. Mohler
Pages 355-370
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About this book
The author of this Foreword has recently retired after spending 25 years in academia and 15 years in the pharmaceutical industry. Most of this time has been spent following and, hopefully in some instances, contributing to advancement of the discipline of pharmacokinetics. During the last 40 years, pharmacokinetics has grown from a fledgling in the 1950s to an adult in the 1990s. The late development of the discipline of pharmacokinetics, relative to other disciplines such as chemistry, bio chemistry, and pharmacology, probably stems both from general ignorance of the importance of the time course of concentration-effect relationships in drug therapy and from our technical inability to do anything about it had we been more enlightened. Just as the end of the historical dark ages had to await the beginning of the Carolingian revival, so the end of the pharma co kinetic dark age had to await the discovery of adequate analytical methods and also an intellectual leap of faith to accept that drug action is in some way dependent on receptor site occupancy, and therefore on drug con centration. The recent evolution of pharmacokinetics has occurred in three phases which may be identified as those of discovery, stabilization, and rationaliz ation. The discovery phase, which occurred in the 1950s and 1960s, esta blished the mathematics and concepts of "modern" pharmacokinetics and sought areas of application, ranging from model-independent methods, through compartment approaches, to complex physiological models.
Editors and Affiliations
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Pharmacokinetics/Drug Metabolism Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, USA
Peter G. Welling
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Clinical Research Unit, Department of Psychiatry, Geneva, Switzerland
Luc P. Balant
