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Contemporary Research on Renal Cell Carcinoma

Basic and Clinical Developments

  • Conference proceedings
  • © 1994

Overview

Editors:
  1. Gerd Staehler

    1. Abteilung Urologie und Poliklinik, Chirurgische Universitätsklinik, Heidelberg, Germany

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  2. Sigmund Pomer

    1. Abteilung Urologie und Poliklinik, Chirurgische Universitätsklinik, Heidelberg, Germany

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (18 papers)

  1. Front Matter

    Pages I-XII
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  2. Clinical Research

    1. Front Matter

      Pages 1-1
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    2. The Role of Nephrectomy in Metastatic Renal Cell Carcinoma

      • E. A. Klein
      Pages 3-9

    3. Possibilities and Limitations of Surgery for Liver Metastases of Renal Cell Cancer

      • P. Hohenberger
      Pages 10-18

    4. The Role of Bone Surgery for Immunotherapy in Disseminated Renal Cell Cancer

      • W. Friedl, T. Fritz
      Pages 19-29

    5. Survival After Lung Surgery for Metastatic Renal Cancer

      • D. Branscheid, S. Pomer, S. Krysa, I. Vogt-Moykopf
      Pages 30-38

    6. Partial Nephrectomy for Renal Cell Carcinoma: Clinical and Biological Considerations

      • E. A. Klein
      Pages 39-46

    7. Investigation of the Tumor Capsule in Renal Cell Carcinoma and Its Significance for Treatment

      • W. de Riese, E. P. Allhoff, S. Liedke, C. G. Stief, M. Werner, H. Kirchner et al.
      Pages 47-55

    8. Interleukin-2 Therapy: Report on 129 Patients and Three Different Schedules

      • S. Négrier, A. Mercatello, B. Coronel, F. Lanier, M. O. Heilmann, Y. Merrouche et al.
      Pages 56-62

    9. Response According to Site of Metastases in Patients with Metastatic RCC (Renal Cell Carcinoma) During Treatment with Interferon Alpha in Combination with 5-Fluorouracil

      • A. J. W. Goldschmidt, U. W. Tunn
      Pages 63-65

  3. Basic Research

    1. Front Matter

      Pages 67-67
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    2. Molecular Mapping of the Human 3p Region

      • E. R. Zabarovsky, V. I. Kashuba, Z. Marcsek, E. S. Pokrovskaya, V. Zabarovska, I. Kholodnyuk et al.
      Pages 69-79

    3. Molecular Analysis of Different Loci on Chromosomes 3, 5, and 17 in Sporadic Renal Cell Carcinoma

      • H. Brauch, T. Schadt, T. Hieronymus, D. Komitowski, S. Pomer
      Pages 80-89

    4. Expression of Immediate Early Transcription Factors in Human Renal Cell Tumors

      • T. Strohmeyer, W. Levin, M. Press, P. Effert, D. Slamon
      Pages 90-96

    5. Characterization and Functional Significance of the von Hippel-Lindau Gene in Renal Cell Carcinomas

      • H.-J. H. Decker, S. Klauck, D. I. Smith, C. Huber, B. Seizinger
      Pages 97-103

    6. In Situ Expression of Cytokines in Renal Cell Carcinoma

      • C. Krüger, I. L. Noronha, H. Stein, R. Waldherr
      Pages 104-111

    7. Tumor-Infiltrating Lymphocytes in Renal Cell Carcinoma: Phenotype, Function, and T-Cell Receptor Usage

      • O. G. Segurado, I. Durinovic-Bello, R. Oberneder, M. Kriegmair, A. Hofstetter, G. Riethmüller et al.
      Pages 112-120

    8. Immunological Approaches to Reverse Multidrug Resistance: The Concept of Molecular Targeting

      • G. H. Mickisch
      Pages 121-131

    9. Therapeutic Applications of Monoclonal Antibodies in Combination with Cytokines in Renal Cell Carcinoma

      • J. van Dijk, A. J. M. C. Beniers, J. A. Schalken, G. J. Fleuren, S. O. Warnaar
      Pages 132-140

    10. Tools for Vaccination and Immunotherapy: Internal-Image Anti-idiotype Antibodies Resembling the Renal Cell Carcinoma Associated Antigen G250

      • H. Uemura, F. M. J. Debruyne, E. Okajima, J. A. Schalken, E. Oosterwijk
      Pages 141-147
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Keywords

About this book

The management of advanced renal cell carcinoma is still problematic. Surgery, although the therapy of choice for locally advanced renal tumors, is still controversial as the treatment for metastases. The role of surgery in the management of patients with pulmonary, bony, and liver metastasis is one of the subject matters discussed in this book. Our results with series of patients undergoing resection of metastases from the lung, bone, and liver show that surgery may be appropriate in selected patients with a good performance status, although most of them certainly cannot be cured by this procedure alone, i.e., in the absence of effective adjuvant therapies. As recent developments show, new strategies for immunotherapy of renal cell carcinoma represent a modest advance over traditional approaches in the treatment of this cancer, such as chemo- and radiotherapy. Clinical trials employing recombinant interferon-a and interleukin 2 produced response rates in up to 30% of patients treated, as evidenced by the European Immunotherapy Trials Program. The adverse reactions and the lack of efficacy in the majority of patients warrants the search for new immunotherapeutic approaches.

Editors and Affiliations

  • Abteilung Urologie und Poliklinik, Chirurgische Universitätsklinik, Heidelberg, Germany

    Gerd Staehler, Sigmund Pomer

Bibliographic Information

  • Book Title: Contemporary Research on Renal Cell Carcinoma

  • Book Subtitle: Basic and Clinical Developments

  • Editors: Gerd Staehler, Sigmund Pomer

  • DOI: https://doi.org/10.1007/978-3-642-78609-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-642-78611-2Published: 13 December 2011

  • eBook ISBN: 978-3-642-78609-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 158

  • Number of Illustrations: 3 illustrations in colour

  • Topics: Urology, Oncology, Immunology

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