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Haematology and Blood Transfusion Hämatologie und Bluttransfusion

Acute Leukemias IV

Prognostic Factors and Treatment Strategies

Editors: Büchner, Th., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (Eds.)

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  • ISBN 978-3-642-78350-0
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Softcover $109.00
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About this book

The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans­ plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell biology has resulted in novel therapeutic approaches such as terminal differentiation by all-trans-retinoic acid, modulation of chemotherapy by hematopoietic growth factors such as GM-CSF and enhancement of immunologic control by cytokines such as interleukin 2. New antimicrobial drugs and the application of mostly empiric anti-infectious strategies have helped reducing the therapeutic risk. Thus, a number of recent achievements have provided us with new options in the management of patients with acute leukemias.

Table of contents (43 chapters)

  • The Treatment of Acute Leukemia: Observations by a Marrow Transplanter

    Thomas, E. D.

    Pages 1-5

  • Polymerase Chain Reaction Approach for the Evaluation of Minimal Residual Disease in Acute Leukemia

    Biondi, A. (et al.)

    Pages 9-14

  • Two Subtypes of Therapy-Related Leukemia; Experience from The Copenhagen Series

    Pedersen-Bjergaard, J. (et al.)

    Pages 15-23

  • Incidence, Biologic Features and Treatment Outcome of Myeloid-Antigen-Positive Acute Lymphoblastic Leukemia (My + ALL)

    Ludwig, W. D. (et al.)

    Pages 24-32

  • In Situ Amplification of Rearranged Gene Sequences in Individual Cells for Tracing Clonal Cells in Smears from Blood and Bone Marrow

    Pachmann, K. (et al.)

    Pages 33-37

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-3-642-78350-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-3-642-78352-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Acute Leukemias IV
Book Subtitle
Prognostic Factors and Treatment Strategies
Editors
  • Thomas Büchner
  • W. Hiddemann
  • B. Wörmann
  • G. Schellong
  • J. Ritter
Series Title
Haematology and Blood Transfusion Hämatologie und Bluttransfusion
Series Volume
36
Copyright
1994
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-78350-0
DOI
10.1007/978-3-642-78350-0
Softcover ISBN
978-3-642-78352-4
Series ISSN
0440-0607
Edition Number
1
Number of Pages
XXXVI, 803
Topics