Cerebral Ischemia and Basic Mechanisms

1. Front Matter

   Pages I-XIV

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2. The Window of Opportunity for the Treatment of Cerebral Ischaemia

   1. The Window of Opportunity for the Treatment of Cerebral Ischaemia

      • M. D. O’brien

      Pages 1-5

3. Energy Metabolism

   1. Front Matter

      Pages 7-7

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   2. Uncoupling of Flow and Metabolism in Early Ischemic Stroke

      • W.-D. Heiss, G. R. Fink, M. Huber, K. Herholz, U. Pietrzyk

      Pages 9-18

   3. Recovery from Motor Stroke: Different Patterns of Functional Reorganisation in Individual Patients

      • C. Weiller, R. S. J. Frackowiak

      Pages 19-27

   4. Head Injuries: A Target for Neuroprotection

      • G. M. Teasdale, R. Bullock, J. McCulloch

      Pages 28-35

   5. Changes in the Biophysical Environment of Water Following Focal Brain Ischemia in the Rat

      • J. A. Helpern, R. J. Ordidge, R. A. Knight

      Pages 36-48

4. Acidosis

   1. Front Matter

      Pages 49-49

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   2. Aspects of Acid-Base Homeostasis in Ischemia

      • L. Symon, D. L. Taylor, T. P. Obrenovitch

      Pages 51-57

   3. Acidosis: A Marker for Penumbra or a Target for Treatment?

      • A. J. Strong, E. Monteiro

      Pages 58-63

   4. Astrocytic H+ and Ca2+ Changes: Implications for Ischemic Brain Injury

      • R. P. Kraig, C. D. Lascola

      Pages 64-76

   5. Anoxic Injury of Central Myelinated Axons: Nonsynaptic Ionic Mechanisms

      • B. R. Ransom, S. G. Waxman, P. K. Stys

      Pages 77-90

   6. In Vivo Nuclear Magnetic Resonance Observation of Cerebral Metabolism

      • T. R. Brown

      Pages 91-102

   7. Effects of Extracellular Acidosis on Glial Cell Intracellular pH: Evidence for a Glial Spatial H+-Buffering Mechanism?

      • C. Klawe, C. Volk, O. Kempski

      Pages 103-110

5. Intracellular Messengers

   1. Front Matter

      Pages 111-111

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   2. Calcium Channel Blockers Prevent Delayed Cerebral Ischemia After Intracranial Aneurysmal Subarachnoid Hemorrhage

      • J. S. Meyer, S. Takashima, Y. Terayama

      Pages 113-124

   3. Monosialoganglioside GM1 in Experimental Models of Stroke

      • M. S. Seren, A. Lazzaro, M. C. Comelli, R. Canella, R. Zanoni, D. Guidolin et al.

      Pages 125-129

   4. What Are We Learning from Clinical Trials in Acute Cerebral Ischemia?

      • C. Fieschi, M. Frontoni, M. Fiorelli, M. L. Sacchetti, D. Toni, C. Argentino et al.

      Pages 130-136

   5. Threshold of Calcium Influx After Global and Focal Ischemia: Implications for the Window of Therapeutic Opportunity

      • T. J. De Graba, J. C. Grotta

      Pages 137-146

   6. Non-NMDA Glutamate Receptors in the Regulation of Neuronal Ca2+ and Excitotoxicity

      • R. J. Miller, J. R. Brorson, D. Bleakman, P. S. Chard

      Pages 147-157

In this volume, one of a series of monographs devoted to the problems of cerebral ischemia and related topics, we present the proceedings of an international conference on Cerebral Ischemia and Basic Mechanisms held in Bad Schachen/Lake Constance, Germany in June 1992. The enormous progress in research recently on the basic mechanisms associated with cerebral ischemia has provided greater insight into the pathophysiological mechanisms of reduced brain perfusion and decreased cerebral metabolism. The high technology instrumentation used to unravel the intricacies of cerebral blood flow and metabolism includes positron emission tomography and magnetic resonance imaging. A description of sophisticated neurophysiological techniques will give the reader insight into new models of reversible and irreversible tissue damage and changes at the molecular level have been described. The therapeutic approaches which have developed from this re­ search have been or will be used in clinical trials and will open new avenues in the treatment of stroke. The organizers of the meeting would like to thank the advisory board for its helpful suggestions and the Deutsche Forschungsgemeinschaft and other sponsors for their important support.

• aneurysm
• brain
• brain injury
• cerebral ischemia
• ischemic stroke
• myelin
• nervous system
• neurology
• neurons
• neurophysiology
• neuroprotection
• neurosurgery
• nuclear magnetic resonance (NMR)
• physiology
• spinal cord

• Neurologische Universitätsklinik, Bonn, Germany

  Alexander Hartmann

• Department of Neurology, Texas Medical Center, The University of Texas, Houston, USA

  Frank Yatsu

• Institut für Physiologie, Universität Heidelberg, Heidelberg, Germany

  Wolfgang Kuschinsky

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