Current Topics in Microbiology and Immunology

Neutralization of Animal Viruses

Authors: Dimmock, Nigel J.

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About this book

Understanding neutralization is particularly relevant to an appreciation of the interaction between a virus and its antibody-synthesizing host since it is likely that viruses and the antibody system have evolved in response to reciprocally imposed selective pressures. Neutralization of viruses which only infect non-antibody-synthesizing hosts, while of considerable interest from of points of view is de facto without any such evolutionary signifi­ a number cance. In this second category are viruses of plants, invertebrates, vertebrates below fish in the evolutionary scale which do not synthesize antibody and most bacteria. Viruses of organisms parasitic on or commensal with antibody­ synthesizing vertebrates, such as enteric bacteria, protozoa or metazoan parasites, will be in contac, with antibody at some stage of their existence, and arthropod-borne viruses which have a higher vertebrate as second host are obviously bona fide members of the first category. There is an urgent need to understand the principles by which antibodies inactivate virus infectivity since, at present, we are unable to rationally construct effective vaccines against new agents like the human immuno­ deficiency viruses or to improve existing vaccines. The intention of this volume is to comprehensively review neutralization and where possible to construct a unifying theory which can be tested by experimentation.

Table of contents (26 chapters)

Table of contents (26 chapters)
  • Introduction

    Dimmock, Nigel J.

    Pages 1-2

  • Immunoglobulin G Neutralization by Inhibition of Attachment of Virus to the Cell

    Dimmock, Nigel J.

    Pages 3-9

  • Immunoglobulin G Neutralization Which Does Not Inhibit Attachment of Virus to the Cell

    Dimmock, Nigel J.

    Pages 10-13

  • Immunoglobulin G Neutralization by Aggregation of Virions

    Dimmock, Nigel J.

    Pages 14-16

  • Immunoglobulin G Neutralization Mechanisms Which Operate After Attachment of Virus—Antibody Complex to a Cell Receptor Unit

    Dimmock, Nigel J.

    Pages 17-23

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-77849-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.99
price for USA in USD
  • ISBN 978-3-642-77851-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neutralization of Animal Viruses
Authors
Series Title
Current Topics in Microbiology and Immunology
Series Volume
183
Copyright
1993
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-77849-0
DOI
10.1007/978-3-642-77849-0
Softcover ISBN
978-3-642-77851-3
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VII, 149
Topics