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Neutralization of Animal Viruses

  • Book
  • © 1993

Overview

Authors:
  1. Nigel J. Dimmock

    1. Department of Biological Sciences, University of Warwick, Coventry, UK

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 183)

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Table of contents (26 chapters)

  1. Front Matter

    Pages I-VII
    Download chapter PDF

  2. Introduction

    • Nigel J. Dimmock
    Pages 1-2

  3. Immunoglobulin G Neutralization by Inhibition of Attachment of Virus to the Cell

    • Nigel J. Dimmock
    Pages 3-9

  4. Immunoglobulin G Neutralization Which Does Not Inhibit Attachment of Virus to the Cell

    • Nigel J. Dimmock
    Pages 10-13

  5. Immunoglobulin G Neutralization by Aggregation of Virions

    • Nigel J. Dimmock
    Pages 14-16

  6. Immunoglobulin G Neutralization Mechanisms Which Operate After Attachment of Virus—Antibody Complex to a Cell Receptor Unit

    • Nigel J. Dimmock
    Pages 17-23

  7. Neutralization Which Occurs by Virus Binding Antibody After It Has Attached to a Cell

    • Nigel J. Dimmock
    Pages 24-25

  8. Role of the Cell in Neutralization

    • Nigel J. Dimmock
    Pages 26-29

  9. Antibody-Dependent Enhancement of Infectivity by Neutralizing Antibody: Fc and Complement Receptors

    • Nigel J. Dimmock
    Pages 30-31

  10. Neutralization by Polymeric Immunoglobulin A

    • Nigel J. Dimmock
    Pages 32-33

  11. Neutralization by Immunoglobulin M

    • Nigel J. Dimmock
    Pages 34-36

  12. The Relevance of Immunoglobulin Isotype to Neutralization

    • Nigel J. Dimmock
    Pages 37-38

  13. Viral Carbohydrates, Proteins and Neutralization

    • Nigel J. Dimmock
    Pages 39-43

  14. Properties of Protein and Peptide Antigens Which Elicit Neutralizing Antibody

    • Nigel J. Dimmock
    Pages 44-48

  15. Neutralization In Vivo

    • Nigel J. Dimmock
    Pages 49-54

  16. Complement and Neutralization

    • Nigel J. Dimmock
    Pages 55-57

  17. Neutralization by Inhibition of Release of Progeny Virus from the Infected Cell

    • Nigel J. Dimmock
    Pages 58-58

  18. Change in Virus Proteins and Virion Structure on Binding Antibody, Including Synergistic Neutralization

    • Nigel J. Dimmock
    Pages 59-63

  19. Reversibility of Neutralization

    • Nigel J. Dimmock
    Pages 64-66

  20. Neutralization by Fragments of Antibody

    • Nigel J. Dimmock
    Pages 67-70
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Keywords

About this book

Understanding neutralization is particularly relevant to an appreciation of the interaction between a virus and its antibody-synthesizing host since it is likely that viruses and the antibody system have evolved in response to reciprocally imposed selective pressures. Neutralization of viruses which only infect non-antibody-synthesizing hosts, while of considerable interest from of points of view is de facto without any such evolutionary signifi­ a number cance. In this second category are viruses of plants, invertebrates, vertebrates below fish in the evolutionary scale which do not synthesize antibody and most bacteria. Viruses of organisms parasitic on or commensal with antibody­ synthesizing vertebrates, such as enteric bacteria, protozoa or metazoan parasites, will be in contac, with antibody at some stage of their existence, and arthropod-borne viruses which have a higher vertebrate as second host are obviously bona fide members of the first category. There is an urgent need to understand the principles by which antibodies inactivate virus infectivity since, at present, we are unable to rationally construct effective vaccines against new agents like the human immuno­ deficiency viruses or to improve existing vaccines. The intention of this volume is to comprehensively review neutralization and where possible to construct a unifying theory which can be tested by experimentation.

Authors and Affiliations

  • Department of Biological Sciences, University of Warwick, Coventry, UK

    Nigel J. Dimmock

Bibliographic Information

  • Book Title: Neutralization of Animal Viruses

  • Authors: Nigel J. Dimmock

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-77849-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1993

  • Softcover ISBN: 978-3-642-77851-3Published: 06 December 2011

  • eBook ISBN: 978-3-642-77849-0Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 149

  • Topics: Immunology, Virology, Medical Microbiology

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