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Cytochrome P450

  • Book
  • © 1993

Overview

Editors:
  1. John B. Schenkman

    1. Department of Pharmacology, MC 1505, University of Connecticut Health Center, Farmington, USA

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  2. Helmut Greim

    1. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Neuherberg, Fed. Rep. of Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 105)

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Table of contents (47 chapters)

  1. Front Matter

    Pages I-XXXIV
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  3. The Monooxygenase Reactions

    1. Front Matter

      Pages 87-87
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    2. Metabolic Reactions: Types of Reactions of Cytochrome P450 Enzymes

      • F. P. Guengerich
      Pages 89-103

    3. Metabolic Reactions: Mechanisms of Substrate Oxygenation

      • H. Rein, C. Jung
      Pages 105-122

    4. Liver Cytochrome P450 Metabolism of Endogenous Steroid Hormones, Bile Acids, and Fatty Acids

      • P. Zimniak, D. J. Waxman
      Pages 123-144

    5. Metabolic Reactions: Role of Cytochrome P-450 in the Formation of Reactive Oxygen Species

      • H. Kappus
      Pages 145-154

    6. Cytochrome P450 Structure and Function

      • S. D. Black
      Pages 155-168

    7. Structure of Cytochrome P450: Heme-Binding Site and Heme Reactivity

      • P. R. Ortiz de Montellano, S. E. Graham-Lorence
      Pages 169-181

    8. Cytochrome P450: Probes of Active Site Residues

      • L. S. Kaminsky, R. S. Obach, M. J. Fasco
      Pages 183-194

    9. Structural Models for Substrates and Inhibitors of Cytochrome P450 Enzymes

      • T. Wolff, G. Strobl, H. Greim
      Pages 195-207

  4. Forms of Microsomal P450

    1. Front Matter

      Pages 209-209
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    2. Cytochrome P450 Evolution and Nomenclature

      • F. J. Gonzalez
      Pages 211-219

    3. Cytochrome P450 in Rodents

      • Y. Funae, S. Imaoka
      Pages 221-238

    4. Cytochrome P450 in Humans

      • F. J. Gonzalez
      Pages 239-257
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Keywords

About this book

In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature of this superfamily of enzymes. They also describe the hepatic microsomal enzyme in a large number of species, from mammalian to birds and fish, to plants and unicellular organisms. The different P450 forms in different tissues of the mammalian system are also treated. Regulatory factors of P450 expression receive considerable attention, as do studies on the mechanism of interaction of the microsomal monooxygenase system components. Of particular interest to the reader are, for the first time, a compilation of chapters dedicated to forms of cytochrome P450 involved in steroid hormone biosynthesis. This volume presents the most complete survey of the cytochrome P450 field. It will allow recognition and understanding of the very wide implications this enzyme system has on life processes.

Editors and Affiliations

  • Department of Pharmacology, MC 1505, University of Connecticut Health Center, Farmington, USA

    John B. Schenkman

  • Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung mbH, Neuherberg, Fed. Rep. of Germany

    Helmut Greim

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