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- About this book
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In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature of this superfamily of enzymes. They also describe the hepatic microsomal enzyme in a large number of species, from mammalian to birds and fish, to plants and unicellular organisms. The different P450 forms in different tissues of the mammalian system are also treated. Regulatory factors of P450 expression receive considerable attention, as do studies on the mechanism of interaction of the microsomal monooxygenase system components. Of particular interest to the reader are, for the first time, a compilation of chapters dedicated to forms of cytochrome P450 involved in steroid hormone biosynthesis. This volume presents the most complete survey of the cytochrome P450 field. It will allow recognition and understanding of the very wide implications this enzyme system has on life processes.
- Table of contents (47 chapters)
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Historical Background and Description of the Cytochrome P450 Monooxygenase System
Pages 3-13
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NADPH-Cytochrome P450 Reductase: Function
Pages 15-34
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Protein and Gene Structure and Regulation of NADPH-Cytochrome P450 Oxidoreductase
Pages 35-58
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Localization of Cytochrome P450 in Membranes: Mitochondria
Pages 61-69
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Localization of Cytochrome P450 in Membranes: Reconstituted Systems
Pages 71-85
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Table of contents (47 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Cytochrome P450
- Editors
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- John B. Schenkman
- Helmut Greim
- Series Title
- Handbook of Experimental Pharmacology
- Series Volume
- 105
- Copyright
- 1993
- Publisher
- Springer-Verlag Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- eBook ISBN
- 978-3-642-77763-9
- DOI
- 10.1007/978-3-642-77763-9
- Series ISSN
- 0171-2004
- Edition Number
- 1
- Number of Pages
- XXXIV, 739
- Number of Illustrations
- 1 illustrations in colour
- Topics
