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Risk Assessment of Prenatally-Induced Adverse Health Effects

Editors: Neubert, D., Kavlock, R.J., Merker, H.-J., Klein, J. (Eds.)

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eBook $109.00
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  • ISBN 978-3-642-77753-0
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Softcover $139.00
price for USA in USD
  • ISBN 978-3-642-77755-4
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About this book

Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.

Table of contents (39 chapters)

  • Introduction

    Neubert, Diether (et al.)

    Pages 1-23

  • Risk Assessment for Pharmaceutical Products

    Manson, Jeanne M.

    Pages 27-43

  • Reproductive Toxicity Risk Assessment — Some Questions

    Palmer, Anthony K.

    Pages 45-61

  • Biomarkers of Developmental Neurotoxicity

    Scallet, Andrew C. (et al.)

    Pages 63-77

  • A Call for Increased Flexibility in Current Teratogenicity Testing

    Scott, William J., Jr.

    Pages 79-84

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-642-77753-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $139.00
price for USA in USD
  • ISBN 978-3-642-77755-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Risk Assessment of Prenatally-Induced Adverse Health Effects
Editors
  • Diether Neubert
  • Robert J. Kavlock
  • Hans-Joachim Merker
  • Jane Klein
Copyright
1992
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-77753-0
DOI
10.1007/978-3-642-77753-0
Softcover ISBN
978-3-642-77755-4
Edition Number
1
Number of Pages
XIV, 565
Topics