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Risk Assessment of Prenatally-Induced Adverse Health Effects

  • Conference proceedings
  • © 1992

Overview

Editors:
  1. Diether Neubert

    1. Institut für Toxikologie und Embryopharmakologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Berlin 33, Germany

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  2. Robert J. Kavlock

    1. Developmental Toxicology Division, US Environmental Protection Agency, Health Effects Research Laboratory (MD-71), USA

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  3. Hans-Joachim Merker

    1. Institut für Anatomie, Freie Universität Berlin, Berlin 33, Germany

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  4. Jane Klein

    1. Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin, Berlin 33, Germany

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Table of contents (39 papers)

  1. Front Matter

    Pages I-XIV
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  2. Introduction

    1. Introduction

      • Diether Neubert, Robert J. Kavlock
      Pages 1-23

  3. Basis for Testing in Reproductive Toxicity

    1. Front Matter

      Pages 25-25
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    2. Risk Assessment for Pharmaceutical Products

      • Jeanne M. Manson
      Pages 27-43

    3. Reproductive Toxicity Risk Assessment — Some Questions

      • Anthony K. Palmer
      Pages 45-61

    4. Biomarkers of Developmental Neurotoxicity

      • Andrew C. Scallet, William Slikker Jr.
      Pages 63-77

    5. A Call for Increased Flexibility in Current Teratogenicity Testing

      • William J. Scott Jr.
      Pages 79-84

    6. Specific and Non-Specific Developmental Effects

      • Ludwig Machemer, Ulrich Schmidt, Beate Holzum
      Pages 85-100

  4. Risk Assessment as Practiced in Various Countries

    1. Front Matter

      Pages 101-101
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    2. Assessment of Reproductive Toxicology of Drugs at the Food and Drug Administration

      • Judi Weissinger
      Pages 103-111

    3. New Approaches to Developmental Toxicity Risk Assessment at the U.S. Environmental Protection Agency

      • Robert J. Kavlock, Carole A. Kimmel
      Pages 113-126

    4. Scientific Basis for Risk Assessment (Reproductive Toxicity) for Pesticides as Practiced by the Bundesgesundheitsamt (BGA)

      • Wolfgang Lingk, Maged Younes, Rudolf Pfeil, Roland Solecki
      Pages 127-139

    5. Scientific Basis for Risk Assessment (Reproductive Toxicity) in Ecotoxicology as Practiced by the Federal Environmental Agency (Umweltbundesamt)

      • Wolfgang Heger
      Pages 141-148

    6. General Discussion: Choice of Species

      • Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 149-151

    7. Scientific Basis for Risk Assessment (Reproductive Toxicity) for Medicinal Products as Practiced in Germany and the European Community (EC)

      • Rolf Baß, Beate Ulbrich
      Pages 153-161

    8. Risk Assessment in Reproductive Toxicology as Practiced in South America

      • Francisco J. R. Paumgartten, Eduardo E. Castilla, Roque Monteleone Neto, Helena L. L. Coelho, Sarah H. Costa
      Pages 163-179

    9. Reproductive Hazard Evaluation and Risk Assessment under California’s Proposition 65

      • Gerald F. Chernoff, Steven A. Book
      Pages 181-189

    10. General Discussion: Risk Assessment

      • Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein
      Pages 191-194

  5. Dose-Response Relationships and Quantitative Risk Assessment

    1. Front Matter

      Pages 195-195
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    2. Statistical Problems (and Some Solutions) Associated with Testing for Effects in Developmental Toxicology

      • R. Woodrow Setzer
      Pages 197-209
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Keywords

About this book

Since the thalidomide (Contergan) tragedy about 30 years ago the induction of prenatally-induced morphological or functional defects has been an area of extensive research. Risk assessment of prenatally-induced adverse health effects is still a difficult task from both experimental data as well asfrom observations in humans. In the contributions to this book three major aspects are dealt with: - Quantitative extrapolations of experimental data to the situation possibly relevant for man. - The significance for a risk assessment with respect to man of minor or rare structural abnormalities observed in experimental studies - The future need to assess congenital dysfunctions (e.g. of the hormone or the immune system) beside the present evaulation of structural defects. Limitations as well as gaps of the present knowledge in this area of basic and applied research are pointed out. Since the results of prenatally-induced lesions may manifest themselves not only pre- but often not before late postnatally, numerous aspects of structural and functional abnormaldevelopment must be studied in experimental and clinical investigations.

Editors and Affiliations

  • Institut für Toxikologie und Embryopharmakologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Berlin 33, Germany

    Diether Neubert

  • Developmental Toxicology Division, US Environmental Protection Agency, Health Effects Research Laboratory (MD-71), USA

    Robert J. Kavlock

  • Institut für Anatomie, Freie Universität Berlin, Berlin 33, Germany

    Hans-Joachim Merker

  • Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin, Berlin 33, Germany

    Jane Klein

Bibliographic Information

  • Book Title: Risk Assessment of Prenatally-Induced Adverse Health Effects

  • Editors: Diether Neubert, Robert J. Kavlock, Hans-Joachim Merker, Jane Klein

  • DOI: https://doi.org/10.1007/978-3-642-77753-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1992

  • Softcover ISBN: 978-3-642-77755-4Published: 16 December 2011

  • eBook ISBN: 978-3-642-77753-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 565

  • Topics: Anatomy, Pharmacology/Toxicology, Statistics for Life Sciences, Medicine, Health Sciences, Anthropology

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