Pharmacology of Asthma

1. Front Matter

   Pages I-XVII

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2. The Pathology of Asthma: An Overview

   • L. A. Laitinen, A. Laitinen

   Pages 1-25

3. The Contribution of Inflammatory Cells to the Pathogenesis of Asthma

   • A. G. Alexander, J. W. Wilson, S. T. Holgate, A. B. Kay

   Pages 27-51

4. Inflammatory Mediators

   • P. J. Barnes, K. F. Chung, C. P. Page

   Pages 53-106

5. Pharmacology of Airway Smooth Muscle

   • I. W. Rodger, R. C. Small

   Pages 107-141

6. Neural Mechanisms in Asthma

   • P. J. Barnes

   Pages 143-166

7. Pharmacology and Therapeutics of β-Adrenoceptor Agonists

   • R. G. Goldie, J. W. Paterson, K. M. Lulich

   Pages 167-205

8. Pharmacology of Anti-Asthma Xanthines

   • C. G. A. Persson, R. Pauwels

   Pages 207-225

9. Glucocorticosteroids in Asthma

   • S. F. Smith, C. P. Page, P. J. Barnes, R. J. Flower

   Pages 227-260

10. Pharmacology of Prophylactic Anti-Asthma Drugs

    • L. G. Garland

    Pages 261-290

11. Pathophysiology and Pharmacology of Aspirin-Induced Asthma

    • A. Szczeklik, C. Virchow, M. Schmitz-Schumann

    Pages 291-314

12. Back Matter

    Pages 315-322

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This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter­ nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma­ cological intervention. It is hoped this book will be invaluable for research scientists and clinic­ ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu­ tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures ...................... 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to Investigate the Pathology of Human Asthma ............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks ........................... 2 I. Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . . . . . . . . . . . . . II. Eosinophils ............................................... 7 III.Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack. . . . . .. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . . . . . . . . . . .. . . 12 . . . . . . . . .

• Atemwegeerkrankung
• Atmen
• asthma
• pathophysiology
• physiology

• Department of Pharmacology, King’s College University of London, London, Great Britain

  Clive P. Page

• Department of Thoracic Medicine, National Heart and Lung Institute, London, Great Britain

  Peter J. Barnes

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