Current Topics in Microbiology and Immunology

Immunological Memory

Editors: Gray, David, Sprent, Jonathan (Eds.)

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About this book

Although immunologists know rather a lot about the manif­ estation of immunological memory, an understanding of the mechanism of memory at cellular and biochemical levels eludes us. Indeed, as we shall see, it is not even clear which of the several models used to explain the working of memory approximates to the truth. It is in order to report on approaches to this problem and on recent experimental advances in the field of memory cells that this volume has been put together. In the past 4-5 years cell surface molecules that may enable us to define memory Band T cells have been identified. It may now be possible to ask how memory cells are generated and to define what signals are required during or after antigenic encounter for a cell to enter the memory cell pool rather than to terminally differentiate into an effector cell. The transition from virgin cell to memory cell is clearly accompanied by several biochemical changes. For B cells, isotype switching and somatic mutations (leading to affinity maturation) are well-defined phenomena, although the molecular mechanisms remain mys­ terious. Both have received attention in many excellent reviews of late and so are not considered in detail in this book. Neither switching nor somatic mutation is a feature of peripheral T-cell maturation; biochemical differences between virgin and mem­ ory T cells may only relate to differing activation requirements and possibly changes in the expression of accessory molecules.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Expansion, Selection and Maintenance of Memory B-Cell Clones

    Gray, D. (et al.)

    Pages 1-17

  • The Generation of B-Cell Memory: A Working Hypothesis

    Klinman, N. R. (et al.)

    Pages 19-35

  • The Evolution of B-Cell Clones

    MacLennan, I. C. M. (et al.)

    Pages 37-63

  • Antiviral T-Cell Memory?

    Zinkernagel, R. M.

    Pages 65-77

  • Subsets of Rat CD4+ T Cells Defined by Their Differential Expression of Variants of the CD45 Antigen: Developmental Relationships and In Vitro and In Vivo Functions

    Powrie, F. (et al.)

    Pages 79-96

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-75244-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-75246-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunological Memory
Editors
  • David Gray
  • Jonathan Sprent
Series Title
Current Topics in Microbiology and Immunology
Series Volume
159
Copyright
1990
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-75244-5
DOI
10.1007/978-3-642-75244-5
Softcover ISBN
978-3-642-75246-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
XI, 141
Topics