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Nato ASI Subseries H:

The Early Effects of Radiation on DNA

Editors: Fielden, E.M., O'Neill, Peter (Eds.)

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  • ISBN 978-3-642-75148-6
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About this book

Interest in the biological effects of ionising radiation closely followed the identification of such radiation. The realisation that DNA is the site of genetic infonnation in cells subsequently focussed attention on DNA as an important target in the lethal and mutagenic effects of ionising radiation. Thus radiation effects upon DNA became an important area for fundamental scientific studies by radiation biologists, chemists and physicists. To a first approximation, the concerns of the three disciplines can be divided by time scales: the physical process of energy deposition from photon or charged 16 12 particle and subsequent relaxation (-10- to 10- secs), followed by chemical 12 2 reactions (- 10- to 10 secs), and fmally, the expression of biological effect (minutes to years). Thus, the concept of 'early processes' conveys different ideas to different scientists, although they are all interrelated. To attempt to describe in any detail all these processes is a mammoth task which is not made easier by the different conventions and experimental approaches of the three disciplines. However, the recent advances in all these scientific areas seemed, to the organisers at least, to offer the opportunity to stimulate more active interaction between physicists, chemists and biologists. With this in mind, a multi-disciplinary workshop was organised, which brought together some fifty scientists to present their own specialist interests and, through extensive discussion, explore which problems are of high priority and require input from the different disciplines to resolve them.

Table of contents (49 chapters)

  • Mechanisms of Radiation Action on DNA in Model Systems - Their Relevance to Cellular DNA

    Ward, J. F.

    Pages 1-16

  • Biophysical Models of Radiation Action - Development of Simulation Codes

    Paretzke, Herwig G.

    Pages 17-32

  • Links Between Radiation Track Structure, Radiochemical Species, and Cell Survival

    Brenner, D. J. (et al.)

    Pages 33-48

  • A Kinetic Investigation of the Mechanisms of Radiation-Induced Strand Breakage in DNA Model Systems

    Jones, George D. D. (et al.)

    Pages 49-50

  • Discussion on Interdisciplinary Approach to Radiation Action

    O’Neill, P.

    Pages 51-54

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-642-75148-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.00
price for USA in USD
  • ISBN 978-3-642-75150-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Early Effects of Radiation on DNA
Editors
  • E.M. Fielden
  • Peter O'Neill
Series Title
Nato ASI Subseries H:
Series Volume
54
Copyright
1991
Publisher
Springer-Verlag Berlin Heidelberg
Copyright Holder
Springer-Verlag Berlin Heidelberg
eBook ISBN
978-3-642-75148-6
DOI
10.1007/978-3-642-75148-6
Softcover ISBN
978-3-642-75150-9
Series ISSN
1010-8793
Edition Number
1
Number of Pages
XII, 430
Topics